Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 3/20 | 0.64 |
| ▸ | NOS1 | P29475 | 3/20 | 0.64 |
| ▸ | NOS2 | P35228 | 3/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | SLC7A5 | Q01650 | 6/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.53 |
| ▸ | ALPI | P09923 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | XIAP | P98170 | 1/20 | 0.53 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.47 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.47 |
| ▸ | CASR | P41180 | 1/20 | 0.47 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7279140 | 1.00 | NOS3 (0.64) | NOS3NOS1NOS2NPSR1SLC7A5 | |
| SCHEMBL22690013 | 0.89 | NOS3 (0.62) | NOS3NOS1NOS2SLC7A5PTGS1 | |
| SCHEMBL22690011 | 0.89 | NOS3 (0.62) | NOS3NOS1NOS2SLC7A5PTGS1 | |
| SCHEMBL22689884 | 0.87 | NOS3 (0.59) | NOS3NOS1NOS2SLC7A5PTGS1 | |
| SCHEMBL22689885 | 0.87 | NOS3 (0.59) | NOS3NOS1NOS2SLC7A5PTGS1 | |
| SCHEMBL29550581 | 0.87 | NOS3 (0.59) | NOS3NOS1NOS2SLC7A5PTGS1 | |
| SCHEMBL22442158 | 0.86 | NOS3 (0.68) | NOS3NOS1NOS2SLC7A5PTGS1 | |
| SCHEMBL22442159 | 0.86 | NOS3 (0.68) | NOS3NOS1NOS2SLC7A5PTGS1 | |
| SCHEMBL16861149 | 0.86 | NOS3 (0.64) | NOS3NOS1NOS2SLC7A5PTGS1 | |
| SCHEMBL22689782 | 0.86 | NOS3 (0.64) | NOS3NOS1NOS2SLC7A5PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12359192-B2 | Methods and compositions for display of macrocyclic peptides | UNIVERSITY OF ROCHESTER (US) | 2025-07-15 | — | — | US | claimed |
| US-20250197448-A1 | CYCLOPEPTIBODIES AND USES THEREOF | UNIVERSITY OF ROCHESTER (US) | 2025-06-19 | — | — | US | claimed |
| EP-4490202-A1 | CYCLOPEPTIBODIES AND USES THEREOF | University of Rochester (US) | 2025-01-15 | — | — | EP | claimed |
| WO-2023173084-A9 | CYCLOPEPTIBODIES AND USES THEREOF | UNIVERSITY OF ROCHESTER (US) | 2023-12-14 | — | — | WO | claimed |
| WO-2023173084-A1 | CYCLOPEPTIBODIES AND USES THEREOF | UNIVERSITY OF ROCHESTER (US) | 2023-09-14 | — | — | WO | claimed |
| EP-3087088-B1 | METHODS AND COMPOSITIONS FOR RIBOSOMAL SYNTHESIS OF MACROCYCLIC PEPTIDES | UNIV ROCHESTER (US) | 2022-05-25 | — | — | EP | claimed |
| US-20200299675-A1 | Methods and Compositions for Display of Macrocyclic Peptides | UNIVERSITY OF ROCHESTER | 2020-09-24 | — | — | US | claimed |
| US-10544191-B2 | Methods and compositions for ribosomal synthesis of macrocyclic peptides | UNIVERSITY OF ROCHESTER (US) | 2020-01-28 | — | — | US | claimed |
| US-20160355552-A1 | METHODS AND COMPOSITIONS FOR RIBOSOMAL SYNTHESIS OF MACROCYCLIC PEPTIDES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-12-08 | — | — | US | claimed |
| EP-3087088-A2 | METHODS AND COMPOSITIONS FOR RIBOSOMAL SYNTHESIS OF MACROCYCLIC PEPTIDES | University Of Rochester (US) | 2016-11-02 | — | — | EP | claimed |
| WO-2015100277-A9 | METHODS AND COMPOSITIONS FOR RIBOSOMAL SYNTHESIS OF MACROCYCLIC PEPTIDES | UNIVERSITY OF ROCHESTER (US) | 2015-10-01 | — | — | WO | claimed |
| WO-2015100277-A2 | METHODS AND COMPOSITIONS FOR RIBOSOMAL SYNTHESIS OF MACROCYCLIC PEPTIDES | UNIVERSITY OF ROCHESTER (US) | 2015-07-02 | — | — | WO | claimed |
| US-12359192-B2 | Methods and compositions for display of macrocyclic peptides | UNIVERSITY OF ROCHESTER (US) | 2025-07-15 | — | — | US | disclosed |
| US-20250197448-A1 | CYCLOPEPTIBODIES AND USES THEREOF | UNIVERSITY OF ROCHESTER (US) | 2025-06-19 | — | — | US | disclosed |
| EP-4490202-A1 | CYCLOPEPTIBODIES AND USES THEREOF | University of Rochester (US) | 2025-01-15 | — | — | EP | disclosed |
| WO-2023173084-A9 | CYCLOPEPTIBODIES AND USES THEREOF | UNIVERSITY OF ROCHESTER (US) | 2023-12-14 | — | — | WO | disclosed |
| US-4766110-A | INHIBITS ANGIOTENSIN CONVERTING ENZYME, HYPOTENSIVE AGENTS | RYAN JAMES W (US) | 1988-08-23 | — | — | US | disclosed |
| EP-0073143-B1 | NOVEL COMPLEX AMIDO AND IMIDO DERIVATIVES OF CARBOXYALKYL PEPTIDES AND THIOETHERS AND ETHERS OF PEPTIDES | Ryan, James Walter (US) | 1985-11-21 | — | — | EP | disclosed |
| EP-0073143-A2 | Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides | Ryan, James Walter (US) | 1983-03-02 | — | — | EP | disclosed |
| EP-0048159-A2 | Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents | UNIVERSITY OF MIAMI (US) | 1982-03-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12359192-B2 | Methods and compositions for display of macrocyclic peptides | NGLY1, MICA, MRPL21 | NOS3 4493/4885NOS1 4676/4885NOS2 4613/4885 |
| US-10544191-B2 | Methods and compositions for ribosomal synthesis of macrocyclic peptides | MRPS27, MRPL21, RPLP2 | NOS3 4125/4885NOS1 4160/4885NOS2 4279/4885 |
| US-20250197448-A1 | CYCLOPEPTIBODIES AND USES THEREOF | FCGR3B, FCGRT, FCGR2A | NOS3 2600/4885NOS1 2714/4885NOS2 2202/4885 |
| US-20160355552-A1 | METHODS AND COMPOSITIONS FOR RIBOSOMAL SYNTHESIS OF MACROCYCLIC PEPTIDES | MRPS27, MRPL21, RPLP2 | NOS3 4125/4885NOS1 4160/4885NOS2 4279/4885 |
| US-20200299675-A1 | Methods and Compositions for Display of Macrocyclic Peptides | SPOUT1, NGLY1, VIP | NOS3 4587/4885NOS1 4588/4885NOS2 4663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.