Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 7/20 | 0.48 |
| ▸ | TYK2 | P29597 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | ELAVL1 | Q15717 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28181760 | 0.82 | SIRT2 (0.60) | SIRT2SIRT1 | |
| SCHEMBL5026846 | 0.76 | JAK3 (0.50) | SYKTYK2 | |
| SCHEMBL27952336 | 0.74 | SIRT2 (0.54) | AKR1C3AKR1C2MAPTSYKMEN1 | |
| SCHEMBL5025114 | 0.73 | SYK (0.74) | SYK | |
| SCHEMBL10594653 | 0.73 | MKNK2 (0.41) | MAPTGAAKDM4EALDH1A1GLA | |
| SCHEMBL9650585 | 0.73 | MAP4K4 (0.41) | MAPTGAAKDM4EALDH1A1THRB | |
| SCHEMBL1095966 | 0.71 | ALDH1A1 (0.50) | MAPTGAAKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL9409101 | 0.69 | MAPT (0.54) | AKR1C3AKR1C2MAPTGAAKDM4E | |
| SCHEMBL4647745 | 0.69 | ALDH1A1 (0.55) | AKR1C3AKR1C2MAPTGAAKDM4E | |
| SCHEMBL9419698 | 0.69 | NQO2 (0.47) | MAPTGAAKDM4EALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |