Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11697720 | 0.82 | ALDH1A1 (0.50) | MAPTL3MBTL1MAPK1CYP1A2CYP3A4 | |
| SCHEMBL26545616 | 0.81 | ALDH1A1 (0.49) | MAPTL3MBTL1MAPK1CYP1A2CYP3A4 | |
| SCHEMBL19928087 | 0.80 | ALDH1A1 (0.52) | MAPTL3MBTL1MAPK1CYP1A2CYP3A4 | |
| SCHEMBL11695567 | 0.79 | HSD17B10 (0.54) | MAPTL3MBTL1MAPK1CYP1A2CYP3A4 | |
| SCHEMBL7945836 | 0.79 | KMT2A (0.52) | MAPTL3MBTL1MAPK1CYP1A2CYP3A4 | |
| SCHEMBL9319273 | 0.79 | KMT2A (0.52) | MAPTL3MBTL1MAPK1CYP1A2CYP3A4 | |
| SCHEMBL9319278 | 0.79 | KMT2A (0.52) | MAPTL3MBTL1MAPK1CYP1A2CYP3A4 | |
| SCHEMBL16806060 | 0.78 | ALDH1A1 (0.50) | MAPTL3MBTL1MAPK1CYP1A2CYP3A4 | |
| SCHEMBL16806066 | 0.78 | ALDH1A1 (0.50) | MAPTL3MBTL1MAPK1CYP1A2CYP3A4 | |
| SCHEMBL9026246 | 0.78 | ALDH1A1 (0.50) | MAPTL3MBTL1MAPK1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904457-A2 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | Rigel Pharmaceuticals, Inc. (US) | 2008-04-02 | — | — | EP | disclosed |
| WO-2006133426-A2 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2006-12-14 | — | — | WO | disclosed |