Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | LDHB | P07195 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 4/20 | 0.32 |
| ▸ | GABRD | O14764 | 4/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL17923538 | 0.90 | FFAR3 (0.44) | ACHETP53SLC7A5NOS3NOS1 | |
| SCHEMBL669306 | 0.86 | — | — | |
| Succinic Acid SCHEMBL27675822 | 0.83 | GABRP (0.48) | LMNAGABRPGABRDGABRA1GABRB1 | |
| Hydrochloric Acid SCHEMBL867904 | 0.82 | NOS3 (0.42) | NOS3NOS1NOS2ALDH1A1 | |
| Water SCHEMBL20837969 | 0.82 | — | — | |
| Bromide SCHEMBL14994189 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL167943 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL21409696 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL9847617 | 0.82 | NOS3 (0.42) | NOS3NOS1NOS2ALDH1A1 | |
| SCHEMBL28735037 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111185478-A | Method for restoring cadmium-polluted soil based on switch surfactant | 昆明理工大学 | 2020-05-22 | — | — | CN | claimed |
| CN-111185478-A | Method for restoring cadmium-polluted soil based on switch surfactant | 昆明理工大学 | 2020-05-22 | — | — | CN | disclosed |
| CN-103170639-A | Method for preparing nano palladium by using amidino surface active agent micro emulsion | UNIV JIANGNAN | 2013-06-26 | — | — | CN | disclosed |
| EP-1957434-A1 | REVERSIBLY SWITCHABLE SURFACTANTS AND METHODS OF USE THEREOF | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007056859-A1 | REVERSIBLY SWITCHABLE SURFACTANTS AND METHODS OF USE THEREOF | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2007-05-24 | — | — | WO | disclosed |