SCHEMBL5025936

SCHEMBL5025936

Cc1cc(O)c(C(C)(C)C)c(Nc2ccccc2)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.52
CXCR2 P25025 3/20 0.47
NPSR1 Q6W5P4 2/20 0.42
HPGD P15428 2/20 0.41
L3MBTL1 Q9Y468 1/20 0.40
GAA P10253 4/20 0.38
TSHR P16473 2/20 0.38
CYP3A4 P08684 1/20 0.38
RAB9A P51151 2/20 0.38
NPC1 O15118 1/20 0.38
MAPT P10636 3/20 0.37
TDP1 Q9NUW8 2/20 0.37
ALDH1A1 P00352 1/20 0.37
MEN1 O00255 3/20 0.37
KMT2A Q03164 3/20 0.37
TAS2R14 Q9NYV8 1/20 0.37
RAPGEF4 Q8WZA2 1/20 0.37
KCNMA1 Q12791 1/20 0.36
KDM4E B2RXH2 2/20 0.36
MAPK1 P28482 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31047645 0.75 CXCR2 (0.73) ATMCXCR2NPSR1HPGDL3MBTL1
SCHEMBL4707292 0.75 CXCR2 (0.73) ATMCXCR2NPSR1HPGDL3MBTL1
SCHEMBL7934312 0.75 CXCR2 (0.73) ATMCXCR2NPSR1HPGDL3MBTL1
SCHEMBL9742612 0.73 SELL (0.52) HPGDGAATSHRCYP3A4MAPT
SCHEMBL7127494 0.72 NPSR1 (0.49) NPSR1HPGDGAACYP3A4RAB9A
SCHEMBL22914813 0.71 ALDH1A1 (0.50) CXCR2HPGDL3MBTL1GAATSHR
SCHEMBL23908289 0.71 NPSR1 (0.50) ATMCXCR2NPSR1HPGDL3MBTL1
SCHEMBL24237114 0.69 NPSR1 (0.48) ATMCXCR2NPSR1HPGDL3MBTL1
Diphenylamine SCHEMBL10491490 0.69 HPGD (0.58) ATMCXCR2NPSR1HPGDL3MBTL1
SCHEMBL28187383 0.69 NPSR1 (0.57) ATMNPSR1HPGDL3MBTL1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7267914-B2 Electrophotographic photoconductor, process cartridge, image forming apparatus and image forming method RICOH COMPANY, LTD. (JP) 2007-09-11 US claimed
US-7348115-B2 Electrophotographic photoconductor, process cartridge, image forming apparatus and image forming method RICOH COMPANY, LTD. (JP) 2008-03-25 US disclosed
US-7267914-B2 Electrophotographic photoconductor, process cartridge, image forming apparatus and image forming method RICOH COMPANY, LTD. (JP) 2007-09-11 US disclosed
US-20050170271-A1 Electrophotographic photoconductor, process cartridge, image forming apparatus and image forming method YAMANAMI HIROFUMI (JP) 2005-08-04 US disclosed
US-20030232265-A1 Electrophotographic photoconductor, process cartridge, image forming apparatus and image forming method RICOH COMPANY, LTD. (JP) 2003-12-18 US disclosed
EP-1324139-A2 Electrophotographic photoconductor, process cartridge, image forming apparatus and image forming method Ricoh Company, Ltd. (JP) 2003-07-02 EP disclosed