Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.46 |
| ▸ | BCL2 | P10415 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | RHEB | Q15382 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAT2A | P31153 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13429078 | 0.82 | TP53 (0.54) | TP53SMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL2797754 | 0.77 | TP53 (1.00) | TP53SMN1; SMN2LMNAKDM4ECA9 | |
| SCHEMBL3213666 | 0.76 | TP53 (0.48) | TP53SMN1; SMN2KDM4EPARP1RHEB | |
| SCHEMBL13429129 | 0.71 | RHEB (0.50) | SMN1; SMN2LMNAKDM4EGAAALDH1A1 | |
| SCHEMBL3217241 | 0.70 | MEN1 (0.60) | TP53SMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL13429180 | 0.69 | CYP1A2 (0.57) | SMN1; SMN2KDM4EGLAGAAALDH1A1 | |
| SCHEMBL29410772 | 0.69 | TP53 (0.70) | TP53SMN1; SMN2LMNAKDM4ECA9 | |
| SCHEMBL2796184 | 0.69 | TP53 (0.70) | TP53SMN1; SMN2LMNAKDM4ECA9 | |
| SCHEMBL3151814 | 0.68 | LMNA (1.00) | TP53SMN1; SMN2LMNAKDM4ECA9 | |
| SCHEMBL7465309 | 0.67 | LMNA (0.51) | SMN1; SMN2LMNAMCL1GLAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005051974-A2 | NOVEL MOLECULES FOR REGULATING CELL DEATH | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-06-09 | — | — | WO | claimed |
| US-20050038051-A1 | Novel molecules for regulating cell death | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-02-17 | — | — | US | claimed |
| US-8450333-B2 | Molecules for regulating cell death | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-05-28 | — | — | US | disclosed |
| US-20080287473-A1 | NOVEL MOLECULES FOR REGULATING CELL DEATH | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-11-20 | — | — | US | disclosed |
| WO-2005051974-A2 | NOVEL MOLECULES FOR REGULATING CELL DEATH | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-06-09 | — | — | WO | disclosed |
| US-20050038051-A1 | Novel molecules for regulating cell death | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287473-A1 | NOVEL MOLECULES FOR REGULATING CELL DEATH | AIFM1, BAX, HSPE1 | TP53 101/4885SMN1; SMN2 2685/4885LMNA 1467/4885 |
| US-20050038051-A1 | Novel molecules for regulating cell death | AIFM1, BAX, HSPE1 | TP53 101/4885SMN1; SMN2 2685/4885LMNA 1467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.