Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 1/20 | 0.60 |
| ▸ | BRAF | P15056 | 8/20 | 0.58 |
| ▸ | PDE4A | P27815 | 5/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.58 |
| ▸ | IKBKB | O14920 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | EEF2K | O00418 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5026962 | 0.92 | LIMK1 (0.53) | LIMK1BRAFPDE4APDE4BPDE4C | |
| SCHEMBL5024691 | 0.86 | LHCGR (0.57) | LIMK1BRAFPDE4APDE4BPDE4C | |
| SCHEMBL5026123 | 0.86 | KDM4E (0.54) | LIMK1BRAFPDE4APDE4BPDE4C | |
| SCHEMBL4419064 | 0.85 | BRAF (0.64) | LIMK1BRAFPDE4APDE4BPDE4C | |
| SCHEMBL5024656 | 0.84 | LIMK1 (0.52) | LIMK1BRAFPDE4APDE4BPDE4C | |
| SCHEMBL5030909 | 0.82 | BRAF (0.61) | LIMK1BRAFPDE4APDE4BPDE4C | |
| SCHEMBL5026126 | 0.80 | BRAF (0.59) | LIMK1BRAFPDE4APDE4BPDE4C | |
| SCHEMBL6110282 | 0.79 | IKBKB (0.68) | LIMK1IKBKBMAPTUSP2HTT | |
| SCHEMBL27536473 | 0.79 | LIMK1 (0.48) | LIMK1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5030956 | 0.79 | BRAF (0.47) | LIMK1BRAFPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7375109-B2 | Glycine-substituted thieno[2,3-d]pyrimidines with combined LH and FSH agonistic activity | N.V. ORGANON (NL) | 2008-05-20 | — | — | US | disclosed |
| US-20040180907-A1 | Glycine-substituted thieno{2,3-d}pyrimidines with combined lh and fsh agonistic activity | MERCK SHARP & DOHME B.V. (NL) | 2004-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180907-A1 | Glycine-substituted thieno{2,3-d}pyrimidines with combined lh and fsh agonistic activity | FSHR, GNRHR, LHCGR | LIMK1 4850/4885BRAF 4677/4885PDE4A 638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.