Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 6/20 | 0.68 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | EEF2K | O00418 | 7/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1176458 | 0.81 | IKBKB (0.68) | IKBKBLIMK1MAPTHTTUSP2 | |
| SCHEMBL4198561 | 0.81 | IKBKB (1.00) | IKBKBLIMK1MAPTHTTUSP2 | |
| SCHEMBL6110291 | 0.80 | KMT2A (0.71) | IKBKBLIMK1MAPTHTTNPC1 | |
| SCHEMBL5026165 | 0.79 | LIMK1 (0.60) | IKBKBLIMK1MAPTHTTUSP2 | |
| SCHEMBL6111195 | 0.79 | IKBKB (0.56) | IKBKBLIMK1MAPTHTTNPC1 | |
| SCHEMBL1175798 | 0.78 | IKBKB (0.64) | IKBKBLIMK1MAPTHTTUSP2 | |
| SCHEMBL6111409 | 0.78 | IKBKB (0.64) | IKBKBLIMK1MAPTHTTL3MBTL1 | |
| SCHEMBL6111218 | 0.77 | IKBKB (0.66) | IKBKBLIMK1MAPTHTTHSD17B10 | |
| SCHEMBL1176286 | 0.77 | IKBKB (0.62) | IKBKBLIMK1MAPTHTTUSP2 | |
| SCHEMBL6111488 | 0.76 | EEF2K (0.59) | IKBKBLIMK1MAPTHTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006010568-A2 | SUBSTITUTED PYRIDO[3',2':4,5]THIENO[3,2-D]PYRIMIDINE-2,4(1 H,3H)-DIONES AND -4(3H)-ONES, PYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDINE-2,4(1 H,3H)-DIONES AND -4(3H)-ONES, AND USE THEREOF AS INHIBITORS OF TNF-ALPHA RELEASE | CURACYTE DISCOVERY GMBH (DE) | 2006-02-02 | — | — | WO | disclosed |