Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 3/20 | 0.39 |
| ▸ | KRAS | P01116 | 7/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | BAX | Q07812 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL609239 | 0.85 | CHRM2 (0.52) | TSPOKRASCHRM2CHRM4CHRM1 | |
| SCHEMBL5024535 | 0.83 | MAPT (0.36) | TSPOKRASBAXMAPTTP53 | |
| SCHEMBL5022633 | 0.83 | BAX (0.56) | BAXMAPTTP53CYP3A4ALOX15 | |
| SCHEMBL5025352 | 0.83 | BAX (0.56) | BAXMAPTTP53CYP3A4ALOX15 | |
| SCHEMBL5022555 | 0.82 | BAX (0.43) | TSPOKRASBAXMAPTTP53 | |
| SCHEMBL5025317 | 0.79 | MEN1 (0.62) | BAXMAPTTP53CYP3A4ALOX15 | |
| SCHEMBL5025287 | 0.79 | MEN1 (0.62) | BAXMAPTTP53CYP3A4ALOX15 | |
| SCHEMBL5022677 | 0.79 | MEN1 (0.62) | BAXMAPTTP53CYP3A4ALOX15 | |
| SCHEMBL5026838 | 0.76 | KMT2A (0.39) | TSPOBAXMAPTTP53CYP3A4 | |
| SCHEMBL5026836 | 0.76 | KRAS (0.46) | TSPOKRASBAXMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237887-B1 | 9-(PIPERAZINYLALKYL)CARBAZOLES AS BAX-MODULATORS | SERONO LAB (CH) | 2008-06-04 | — | — | EP | claimed |