Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 4/20 | 0.46 |
| ▸ | TSPO | P30536 | 2/20 | 0.43 |
| ▸ | BAX | Q07812 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.38 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL607343 | 0.83 | BAX (0.61) | KRASTSPOBAXMAPTTP53 | |
| SCHEMBL609239 | 0.82 | CHRM2 (0.52) | KRASTSPO | |
| SCHEMBL5087737 | 0.80 | BAX (0.67) | BAXMAPTTP53CYP3A4ALOX15 | |
| SCHEMBL5110159 | 0.80 | BAX (0.67) | BAXMAPTTP53CYP3A4ALOX15 | |
| SCHEMBL5025392 | 0.80 | BAX (0.67) | BAXMAPTTP53CYP3A4ALOX15 | |
| SCHEMBL608957 | 0.79 | CCR1 (0.47) | KRASTSPOMAPTMEN1KMT2A | |
| SCHEMBL5022531 | 0.79 | BAX (0.50) | KRASBAXMAPTTP53CYP3A4 | |
| SCHEMBL5024609 | 0.79 | MAPT (0.41) | KRASTSPOBAXMAPTTP53 | |
| SCHEMBL5026847 | 0.76 | TSPO (0.39) | KRASTSPOBAXMAPTTP53 | |
| SCHEMBL5026850 | 0.75 | MEN1 (0.73) | BAXMAPTTP53CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237887-B1 | 9-(PIPERAZINYLALKYL)CARBAZOLES AS BAX-MODULATORS | SERONO LAB (CH) | 2008-06-04 | — | — | EP | claimed |