Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.88 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.88 |
| ▸ | RAD52 | P43351 | 2/20 | 0.88 |
| ▸ | BAX | Q07812 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 4/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.70 |
| ▸ | TP53 | P04637 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.63 |
| ▸ | BACE1 | P56817 | 1/20 | 0.59 |
| ▸ | DNM1 | Q05193 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1305296 | 0.94 | MEN1 (0.78) | MEN1KMT2ARAD52BAXMAPT | |
| SCHEMBL6819686 | 0.93 | BAX (0.82) | MEN1KMT2ARAD52BAXMAPT | |
| SCHEMBL411279 | 0.92 | KMT2A (0.78) | MEN1KMT2ARAD52BAXMAPT | |
| SCHEMBL607333 | 0.91 | BAX (0.88) | MEN1KMT2ARAD52BAXMAPT | |
| SCHEMBL608294 | 0.91 | BAX (0.88) | MEN1KMT2ARAD52BAXMAPT | |
| SCHEMBL607334 | 0.91 | BAX (0.88) | MEN1KMT2ARAD52BAXMAPT | |
| SCHEMBL5024544 | 0.91 | MEN1 (0.73) | MEN1KMT2ARAD52BAXMAPT | |
| SCHEMBL5024534 | 0.91 | MEN1 (0.73) | MEN1KMT2ARAD52BAXMAPT | |
| SCHEMBL5026850 | 0.91 | MEN1 (0.73) | MEN1KMT2ARAD52BAXMAPT | |
| SCHEMBL610230 | 0.91 | MEN1 (0.73) | MEN1KMT2ARAD52BAXMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004020422-A1 | 1, 4- SUBSTITUTED PIPERIDINE DERIVATIVES AND USE THEREOF AS BASE-INHIBITORS IN TREATMENT OF ALZHEIMER'S DISEASE | DE NOVO PHARMACEUTICALS LIMITED (GB) | 2004-03-11 | — | — | WO | claimed |
| WO-2004020422-A1 | 1, 4- SUBSTITUTED PIPERIDINE DERIVATIVES AND USE THEREOF AS BASE-INHIBITORS IN TREATMENT OF ALZHEIMER'S DISEASE | DE NOVO PHARMACEUTICALS LIMITED (GB) | 2004-03-11 | — | — | WO | disclosed |