Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 6/20 | 0.33 |
| ▸ | HPGD | P15428 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14919911 | 0.92 | MAP2K1 (0.38) | HSD17B10TSHRHTTMAP2K2MAP2K1 | |
| SCHEMBL5035609 | 0.88 | KCNH2 (0.41) | MAP2K2MAP2K1KCNH2 | |
| SCHEMBL5028992 | 0.83 | KCNH2 (0.37) | HSD17B10TSHRHTTMAP2K2MAP2K1 | |
| SCHEMBL5029005 | 0.80 | MAP2K1 (0.40) | MAP2K2MAP2K1KMT2AMEN1MAPT | |
| SCHEMBL5031223 | 0.79 | MAP2K1 (0.42) | MAP2K2MAP2K1KCNH2 | |
| SCHEMBL5031302 | 0.76 | MAP2K1 (0.35) | MAP2K2MAP2K1KCNH2CYP1A2SMN1; SMN2 | |
| SCHEMBL5029051 | 0.75 | MAP2K1 (0.40) | MAP2K2MAP2K1KMT2AMEN1MAPT | |
| SCHEMBL14920264 | 0.74 | MAP2K2 (0.38) | MAP2K2MAP2K1KCNH2HPGDGAA | |
| SCHEMBL13723742 | 0.74 | MAP2K2 (0.38) | MAP2K2MAP2K1KCNH2HPGDGAA | |
| SCHEMBL5028995 | 0.71 | MAP2K2 (0.39) | MAP2K2MAP2K1KCNH2MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1922307-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2008-05-21 | — | — | EP | claimed |
| WO-2007044084-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2007-04-19 | — | — | WO | claimed |