Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 13/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.33 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5029051 | 0.89 | MAP2K1 (0.40) | MAP2K1MAP2K2MAPTNPC1RAB9A | |
| SCHEMBL14919911 | 0.88 | MAP2K1 (0.38) | MAP2K1MAP2K2MAPTNPC1RAB9A | |
| SCHEMBL5029001 | 0.82 | MAP2K1 (0.39) | MAP2K1MAP2K2HPGDMAP2K5EIF2AK1 | |
| SCHEMBL5028996 | 0.80 | HSD17B10 (0.39) | MAP2K1MAP2K2MAPTNPC1RAB9A | |
| SCHEMBL5032125 | 0.77 | MAP2K1 (0.38) | MAP2K1MAP2K2 | |
| SCHEMBL5032110 | 0.75 | MAP2K1 (0.39) | MAP2K1MAP2K2 | |
| SCHEMBL5031223 | 0.74 | MAP2K1 (0.42) | MAP2K1MAP2K2MAP2K5 | |
| SCHEMBL3821432 | 0.74 | MAP2K1 (0.48) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL5029045 | 0.73 | MAP2K1 (0.40) | MAP2K1MAP2K2MAPTNPC1RAB9A | |
| SCHEMBL13723742 | 0.73 | MAP2K2 (0.38) | MAP2K1MAP2K2HPGDMAP2K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1922307-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2008-05-21 | — | — | EP | claimed |
| WO-2007044084-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2007-04-19 | — | — | WO | claimed |