Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 19/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 7/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.41 |
| ▸ | IARS2 | Q9NSE4 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5031223 | 0.92 | MAP2K1 (0.42) | KCNH2MAP2K1MAP2K2PRKCZIARS2 | |
| SCHEMBL5028996 | 0.88 | HSD17B10 (0.39) | KCNH2MAP2K1MAP2K2 | |
| SCHEMBL5035605 | 0.82 | MAP2K1 (0.40) | KCNH2MAP2K1MAP2K2BRAFMAPK1 | |
| SCHEMBL14919911 | 0.79 | MAP2K1 (0.38) | KCNH2MAP2K1MAP2K2PRKCZIARS2 | |
| SCHEMBL5031295 | 0.77 | MAP2K1 (0.44) | KCNH2MAP2K1MAP2K2PRKCZIARS2 | |
| SCHEMBL5031221 | 0.73 | MAP2K1 (0.42) | KCNH2MAP2K1MAP2K2BRAFMAPK1 | |
| SCHEMBL3821432 | 0.73 | MAP2K1 (0.48) | MAP2K1MAP2K2MAP2K5 | |
| SCHEMBL5035606 | 0.73 | MAP2K1 (0.46) | MAP2K1MAP2K2MAP2K5 | |
| SCHEMBL4863539 | 0.71 | KCNH2 (0.56) | KCNH2MAP2K1MAP2K2BRAFMAPK1 | |
| SCHEMBL5028992 | 0.70 | KCNH2 (0.37) | KCNH2MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1922307-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2008-05-21 | — | — | EP | claimed |
| WO-2007044084-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2007-04-19 | — | — | WO | claimed |
| EP-1922307-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007044084-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2007-04-19 | — | — | WO | disclosed |