Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 16/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.32 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5029001 | 0.90 | MAP2K1 (0.39) | MAP2K1MAP2K2MAP2K5EIF2AK1GAA | |
| SCHEMBL5028995 | 0.87 | MAP2K2 (0.39) | MAP2K1MAP2K2NPC1MAPTRAB9A | |
| SCHEMBL5029051 | 0.82 | MAP2K1 (0.40) | MAP2K1MAP2K2NPC1MAPTRAB9A | |
| SCHEMBL5032118 | 0.78 | MAP2K1 (0.36) | MAP2K1MAP2K2 | |
| SCHEMBL14920264 | 0.77 | MAP2K2 (0.38) | MAP2K1MAP2K2MAP2K5GAAHPGD | |
| SCHEMBL13723742 | 0.77 | MAP2K2 (0.38) | MAP2K1MAP2K2MAP2K5GAAHPGD | |
| SCHEMBL5031244 | 0.77 | MAP2K1 (0.40) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL5028992 | 0.75 | KCNH2 (0.37) | MAP2K1MAP2K2GAAHPGD | |
| SCHEMBL5032106 | 0.75 | MAP2K1 (0.37) | MAP2K1MAP2K2 | |
| SCHEMBL5035606 | 0.74 | MAP2K1 (0.46) | MAP2K1MAP2K2MAP2K5EIF2AK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1922307-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007044084-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2007-04-19 | — | — | WO | disclosed |