Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 18/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 7/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.36 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.36 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.36 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.33 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.33 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5035606 | 0.81 | MAP2K1 (0.46) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL2511180 | 0.81 | MAP2K1 (0.45) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL5029045 | 0.77 | MAP2K1 (0.40) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL5554883 | 0.74 | MAP2K1 (0.47) | MAP2K1MAP2K2 | |
| SCHEMBL5035605 | 0.68 | MAP2K1 (0.40) | MAP2K1MAP2K2MAP2K5 | |
| SCHEMBL5029001 | 0.66 | MAP2K1 (0.39) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL5031226 | 0.65 | MAP2K1 (0.48) | MAP2K1MAP2K2 | |
| SCHEMBL4851728 | 0.65 | MAP2K1 (0.58) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL5559975 | 0.64 | MAP2K1 (0.48) | MAP2K1MAP2K2 | |
| SCHEMBL5031221 | 0.64 | MAP2K1 (0.42) | MAP2K1MAP2K2MAP2K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1922307-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007044084-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2007-04-19 | — | — | WO | disclosed |