Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 19/20 | 0.46 |
| ▸ | MAP2K2 | P36507 | 5/20 | 0.46 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.41 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5035605 | 0.87 | MAP2K1 (0.40) | MAP2K1MAP2K2MAP2K5PIM1CAMK2B | |
| SCHEMBL5031244 | 0.81 | MAP2K1 (0.40) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL5031221 | 0.79 | MAP2K1 (0.42) | MAP2K1MAP2K2MAP2K5PIM1CAMK2B | |
| SCHEMBL5029001 | 0.79 | MAP2K1 (0.39) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL5031226 | 0.76 | MAP2K1 (0.48) | MAP2K1MAP2K2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2511180 | 0.76 | MAP2K1 (0.45) | MAP2K1MAP2K2 | |
| SCHEMBL5028992 | 0.75 | KCNH2 (0.37) | MAP2K1MAP2K2CYP3A4CYP2C19 | |
| SCHEMBL5029045 | 0.74 | MAP2K1 (0.40) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL5554883 | 0.73 | MAP2K1 (0.47) | MAP2K1MAP2K2PIM1CAMK2B | |
| SCHEMBL5035609 | 0.73 | KCNH2 (0.41) | MAP2K1MAP2K2MAP2K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1922307-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007044084-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2007-04-19 | — | — | WO | disclosed |