Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP3 | O14638 | 9/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14995676 | 0.85 | CA2 (0.51) | ENPP3CA2CA9CDK1CDK2 | |
| SCHEMBL14995675 | 0.82 | STAT6 (0.39) | KMT2AMAPTCA2CA9CDK1 | |
| SCHEMBL4006171 | 0.77 | SYK (0.65) | PLK4AURKAPDPK1DAPK3JAK2 | |
| SCHEMBL3999707 | 0.74 | SYK (0.64) | PLK4AURKAPDPK1DAPK3JAK2 | |
| SCHEMBL4002720 | 0.68 | SYK (0.64) | PLK4AURKAPDPK1DAPK3JAK2 | |
| SCHEMBL4000659 | 0.67 | AURKA (0.63) | PLK4AURKAPDPK1DAPK3JAK2 | |
| SCHEMBL7169031 | 0.66 | MEN1 (0.49) | TP53KMT2AMAPTBACE1SYK | |
| SCHEMBL4008183 | 0.66 | AURKA (0.69) | PLK4AURKAPDPK1DAPK3JAK2 | |
| SCHEMBL5027956 | 0.66 | EGFR (0.42) | ENPP3TP53THRBKMT2AMAPT | |
| SCHEMBL4001420 | 0.66 | AURKA (0.59) | CA2CA9AURKAJAK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904457-A2 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | Rigel Pharmaceuticals, Inc. (US) | 2008-04-02 | — | — | EP | disclosed |
| WO-2006133426-A2 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2006-12-14 | — | — | WO | disclosed |