Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 2/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 6/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.31 |
| ▸ | ABL1 | P00519 | 2/20 | 0.31 |
| ▸ | BCR | P11274 | 2/20 | 0.31 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.31 |
| ▸ | PLK4 | O00444 | 1/20 | 0.31 |
| ▸ | STK25 | O00506 | 1/20 | 0.31 |
| ▸ | CIT | O14578 | 1/20 | 0.31 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | GAK | O14976 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13927723 | 1.00 | PAK4 (0.33) | PAK4APPTAS1R3TAS1R1KDR | |
| SCHEMBL5031212 | 0.91 | CNR1 (0.37) | PAK4TAS1R3TAS1R1KDRCHEK1 | |
| SCHEMBL5030069 | 0.90 | KCNA3 (0.36) | KDRCHEK1CCNA2CDK2AURKA | |
| SCHEMBL5030025 | 0.90 | CHEK1 (0.35) | PAK4KDRCHEK1CCNA2CDK2 | |
| SCHEMBL6427759 | 0.90 | LMNA (0.35) | ROCK2ROCK1PDPK1 | |
| SCHEMBL5031136 | 0.90 | LMNA (0.35) | ROCK2ROCK1PDPK1 | |
| SCHEMBL13927706 | 0.90 | ROCK2 (0.38) | KDRCHEK1ROCK2ROCK1AURKA | |
| SCHEMBL5098700 | 0.90 | ROCK2 (0.38) | KDRCHEK1ROCK2ROCK1AURKA | |
| SCHEMBL5032382 | 0.90 | CHEK1 (0.37) | PAK4KDRCHEK1ROCK2ROCK1 | |
| SCHEMBL13927717 | 0.90 | CHEK1 (0.37) | PAK4KDRCHEK1ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429609-B2 | Pyrazole compound and medicinal composition containing the same | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-09-30 | — | — | US | disclosed |
| US-20050261339-A1 | Pyrazole compound and medicinal composition containing the same | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261339-A1 | Pyrazole compound and medicinal composition containing the same | CNKSR1, NR3C2, CSNK2B | PAK4 1561/4885APP 4411/4885TAS1R3 2659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.