Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 2/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | KLK1 | P06870 | 1/20 | 0.33 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4135906 | 0.87 | F10 (0.41) | F10PRSS1PRSS2PRSS3HCRTR2 | |
| SCHEMBL679158 | 0.83 | AR (0.47) | ARHTR2AJAK1TYK2SLC6A3 | |
| SCHEMBL19638974 | 0.78 | AR (0.41) | ARHTR2AHCRTR2HCRTR1JAK1 | |
| Hydrochloric Acid SCHEMBL28326198 | 0.74 | IRAK4 (0.36) | F10PRSS1PRSS2PRSS3HCRTR2 | |
| Hydrochloric Acid SCHEMBL28517935 | 0.71 | F2 (0.43) | F10 | |
| SCHEMBL6736896 | 0.71 | POLB (0.47) | ARTSHRALDH1A1POLBGAA | |
| SCHEMBL16950829 | 0.71 | ALDH1A1 (0.39) | JAK1TYK2TSHRALDH1A1NPC1 | |
| SCHEMBL528652 | 0.71 | LMNA (0.43) | JAK1TYK2TSHRALDH1A1NPC1 | |
| SCHEMBL28613887 | 0.70 | KMT2A (0.39) | ARALDH1A1KAT6APOLBGAA | |
| SCHEMBL11229875 | 0.69 | TSHR (0.41) | F10PRSS1PRSS2PRSS3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951244-A2 | CALCILYTIC COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007062370-A2 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-31 | — | — | WO | disclosed |