Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL10949557 | 0.97 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL20732 | 0.97 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL5077427 | 0.94 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL10952183 | 0.94 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL5034928 | 0.94 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL25311384 | 0.94 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL1136109 | 0.94 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL1135949 | 0.94 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL6055779 | 0.94 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL5011330 | 0.94 | CA4 (0.84) | CA4ALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940316-A2 | PRESSURE ATTENUATION DEVICE | Solace Therapeutics, Inc. (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007038476-A9 | PRESSURE ATTENUATION DEVICE | ATTENEUX TECHNOLOGIES INC (US) | 2008-04-03 | — | — | WO | disclosed |
| EP-1572285-A4 | IMPLANTABLE PRESSURE ATTENUATION DEVICE | SOLACE THERAPEUTICS INC (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2007038476-A2 | PRESSURE ATTENUATION DEVICE | ATTENEUX TECHNOLOGIES, INC. (US) | 2007-04-05 | — | — | WO | disclosed |
| EP-1572285-A2 | IMPLANTABLE PRESSURE ATTENUATION DEVICE | Solace Therapeutics, Inc. (US) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004030518-A2 | IMPLANTABLE PRESSURE ATTENUATION DEVICE | SOLACE THERAPEUTICS, INC. (US) | 2004-04-15 | — | — | WO | disclosed |
| EP-0837703-A4 | APPARATUS FOR CONTROLLED FLUID DELIVERY | RIVER MEDICAL INC (US) | 1999-08-25 | — | — | EP | disclosed |
| EP-0837703-A1 | APPARATUS FOR CONTROLLED FLUID DELIVERY | RIVER MEDICAL, INC. (US) | 1998-04-29 | — | — | EP | disclosed |
| WO-1997002849-A1 | APPARATUS FOR CONTROLLED FLUID DELIVERY | RIVER MEDICAL, INC. (US) | 1997-01-30 | — | — | WO | disclosed |
| EP-0748252-A1 | GAS DELIVERY APPARATUS AND COMPOSITIONS FOR INFUSION | RIVER MEDICAL, INC. (US) | 1996-12-18 | — | — | EP | disclosed |
| WO-1995023641-A1 | GAS DELIVERY APPARATUS AND COMPOSITIONS FOR INFUSION | RIVER MEDICAL, INC. (US) | 1995-09-08 | — | — | WO | disclosed |