Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL1301476 | 1.00 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL20732 | 0.97 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL445486 | 0.97 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL5471628 | 0.97 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL10949557 | 0.97 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL25311384 | 0.94 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL379089 | 0.94 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL5011330 | 0.94 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL21569386 | 0.94 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL21569395 | 0.94 | CA4 (0.84) | CA4ALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1722772-A4 | DIETARY SUPPLEMENTATION WITH STOICHIOMETRICALLY SPECIFIC POTASSIUM MAGNESIUM CITRATE | MISSION PHARMA CO (US) | 2008-03-19 | — | — | EP | disclosed |
| EP-1722772-A1 | DIETARY SUPPLEMENTATION WITH STOICHIOMETRICALLY SPECIFIC POTASSIUM MAGNESIUM CITRATE | Mission Pharmacal Company (US) | 2006-11-22 | — | — | EP | disclosed |
| US-7091246-B2 | Dietary supplementation with stoichiometrically specific potassium magnesium citrate | MISSION PHARMACAL CO. (US) | 2006-08-15 | — | — | US | disclosed |
| WO-2005087218-A1 | DIETARY SUPPLEMENTATION WITH STOICHIOMETRICALLY SPECIFIC POTASSIUM MAGNESIUM CITRATE | MISSION PHARMACAL CO. (US) | 2005-09-22 | — | — | WO | disclosed |
| US-20050197402-A1 | Dietary supplementation with stoichiometrically specific potassium magnesium citrate | MISSION PHARMACAL CO. | 2005-09-08 | — | — | US | disclosed |