Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 13/20 | 0.53 |
| ▸ | TNF | P01375 | 1/20 | 0.52 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.52 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2886416 | 0.88 | IL2 (0.52) | IL2TNFSTIM1ORAI1MEN1 | |
| SCHEMBL15249596 | 0.86 | IL2 (0.56) | IL2TNFSTIM1ORAI1MEN1 | |
| SCHEMBL5027397 | 0.85 | IL2 (0.51) | IL2TNFSTIM1ORAI1MEN1 | |
| SCHEMBL8233602 | 0.78 | IL2 (0.48) | IL2TNFSTIM1ORAI1MEN1 | |
| SCHEMBL4762822 | 0.77 | IL2 (0.60) | IL2TNFSTIM1ORAI1MEN1 | |
| SCHEMBL5029739 | 0.76 | IL2 (0.50) | IL2TNFSTIM1ORAI1MEN1 | |
| SCHEMBL12093752 | 0.76 | IL2 (0.57) | IL2TNFSTIM1ORAI1MEN1 | |
| SCHEMBL5033790 | 0.76 | IL2 (0.48) | IL2TNFSTIM1ORAI1MEN1 | |
| SCHEMBL1828207 | 0.75 | IL2 (0.63) | IL2TNFSTIM1ORAI1MEN1 | |
| SCHEMBL4770059 | 0.74 | IL2 (0.62) | IL2TNFSTIM1ORAI1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1983831-A2 | PHENYL AND PYRIDYL COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | Synta Pharmaceuticals Corporation (US) | 2008-10-29 | — | — | EP | claimed |
| WO-2007087429-A2 | PHENYL AND PYRIDYL COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2007-08-02 | — | — | WO | claimed |