SCHEMBL5031052

SCHEMBL5031052

COc1cc(N(C(=O)C(C(N)=O)c2ccc(C(=O)Nc3ccccc3N)cc2)c2cc(OC)c(OC)c(OC)c2)cc(OC)c1OC

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 19/20 0.60
HDAC2 Q92769 4/20 0.54
HDAC3 O15379 4/20 0.54
HDAC6 Q9UBN7 3/20 0.54
HDAC7 Q8WUI4 2/20 0.54
HDAC8 Q9BY41 2/20 0.54
HDAC4 P56524 1/20 0.54
HDAC10 Q969S8 1/20 0.54
HDAC11 Q96DB2 1/20 0.54
HDAC9 Q9UKV0 1/20 0.54
HDAC5 Q9UQL6 1/20 0.54
TUBB4A P04350 1/20 0.54
TUBB P07437 1/20 0.54
TUBA3C P0DPH7 1/20 0.54
TUBA1B P68363 1/20 0.54
TUBA4A P68366 1/20 0.54
TUBB4B P68371 1/20 0.54
TUBB3 Q13509 1/20 0.54
TUBB2A Q13885 1/20 0.54
TUBB8 Q3ZCM7 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5031007 0.86 HDAC1 (0.66) HDAC1HDAC2HDAC3HDAC6HDAC7
SCHEMBL5031042 0.83 HDAC1 (0.71) HDAC1HDAC2HDAC3HDAC6HDAC7
SCHEMBL2108404 0.82 HDAC1 (0.74) HDAC1HDAC2HDAC3HDAC6HDAC7
SCHEMBL5035397 0.79 HDAC1 (0.65) HDAC1HDAC2HDAC3
SCHEMBL1689190 0.79 HDAC1 (0.74) HDAC1HDAC2HDAC3
SCHEMBL1689201 0.78 HDAC1 (0.57) HDAC1HDAC2HDAC3HDAC6HDAC7
SCHEMBL1080608 0.78 ABCB1 (0.69) HDAC1HDAC2HDAC3HDAC6HDAC7
SCHEMBL5031985 0.77 PTGS1 (0.59) HDAC1HDAC2HDAC3
SCHEMBL16892962 0.77 HDAC1 (0.63) HDAC1HDAC2HDAC3HDAC6HDAC7
SCHEMBL5031011 0.76 HDAC1 (0.55) HDAC1HDAC2HDAC3HDAC6HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1896395-A2 MODIFIED MALONATE DERIVATIVES Merck & Co., Inc. (US) 2008-03-12 EP disclosed
WO-2007002248-A2 MODIFIED MALONATE DERIVATIVES MERCK & CO., INC. (US) 2007-01-04 WO disclosed