Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 2/20 | 0.41 |
| ▸ | NOS2 | P35228 | 2/20 | 0.41 |
| ▸ | AXL | P30530 | 5/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3022620 | 1.00 | DPP4 (0.47) | DPP4HDAC8HDAC6IDO1NOS3 | |
| SCHEMBL9984392 | 0.92 | HDAC8 (0.48) | DPP4HDAC8HDAC6IDO1NOS3 | |
| Hydrochloric Acid SCHEMBL382423 | 0.90 | HDAC8 (0.47) | DPP4HDAC8HDAC6IDO1NOS3 | |
| SCHEMBL21460294 | 0.82 | SLC6A2 (0.44) | AXLP2RX7 | |
| SCHEMBL12596703 | 0.77 | PRKCI (0.44) | DPP4AXLCHEK1 | |
| SCHEMBL3125940 | 0.77 | HDAC8 (0.48) | DPP4HDAC8HDAC6IDO1SLC22A12 | |
| SCHEMBL25905013 | 0.77 | HDAC8 (0.48) | DPP4HDAC8HDAC6IDO1SLC22A12 | |
| Hydrochloric Acid SCHEMBL1032875 | 0.76 | PRKCI (0.43) | DPP4AXLCHEK1 | |
| Hydrochloric Acid SCHEMBL1032874 | 0.76 | PRKCI (0.43) | DPP4AXLCHEK1 | |
| SCHEMBL21460253 | 0.75 | DRD2 (0.49) | IDO1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954133-A2 | PYRROLIDINEANILINES | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007065093-A2 | PYRROLIDINEANILINES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-06-07 | — | — | WO | disclosed |