Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 3/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.41 |
| ▸ | PGR | P06401 | 2/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3125940 | 0.82 | HDAC8 (0.48) | HDAC8HDAC6CDK2MAPKAPK2IDO1 | |
| SCHEMBL9984392 | 0.82 | HDAC8 (0.48) | HDAC8HDAC6IDO1DPP4SLC22A12 | |
| Hydrochloric Acid SCHEMBL382423 | 0.81 | HDAC8 (0.47) | HDAC8HDAC6IDO1DPP4SLC22A12 | |
| SCHEMBL24299484 | 0.81 | HDAC8 (0.53) | HDAC8HDAC6IDO1DPP4SLC22A12 | |
| SCHEMBL27169503 | 0.81 | HDAC8 (0.53) | HDAC8HDAC6IDO1DPP4SLC22A12 | |
| SCHEMBL29666012 | 0.79 | TRPA1 (0.53) | SLC22A12AR | |
| SCHEMBL5031297 | 0.77 | DPP4 (0.47) | HDAC8HDAC6IDO1DPP4SLC22A12 | |
| SCHEMBL3022620 | 0.77 | DPP4 (0.47) | HDAC8HDAC6IDO1DPP4SLC22A12 | |
| SCHEMBL25039462 | 0.76 | CHEK1 (0.38) | CDK2MAPKAPK2DPP4SLC22A12IRAK4 | |
| SCHEMBL30279151 | 0.76 | CHEK1 (0.38) | CDK2MAPKAPK2DPP4SLC22A12IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230233690-A1 | ANDROGEN RECEPTOR PROTEIN DEGRADERS | UNIV MICHIGAN REGENTS (US) | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230233690-A1 | ANDROGEN RECEPTOR PROTEIN DEGRADERS | AR, SHBG, CYP19A1 | HDAC8 2474/4885HDAC6 2553/4885CDK2 361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.