Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.35 |
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 8/20 | 0.35 |
| ▸ | CTSS | P25774 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1486212 | 1.00 | NAALAD2 (0.44) | NAALAD2MEN1KMT2AGAACA1 | |
| SCHEMBL11569761 | 0.87 | TDP1 (0.37) | NAALAD2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL1200142 | 0.87 | CA1 (0.35) | NAALAD2MEN1KMT2AGAACA1 | |
| SCHEMBL3785294 | 0.84 | MEN1 (0.40) | NAALAD2MEN1KMT2AGAACA1 | |
| SCHEMBL8915151 | 0.84 | MEN1 (0.40) | NAALAD2MEN1KMT2AGAACA1 | |
| SCHEMBL6793586 | 0.83 | TDP1 (0.50) | NAALAD2MEN1KMT2AGAACA1 | |
| SCHEMBL6791470 | 0.82 | MEN1 (0.36) | NAALAD2MEN1KMT2AGAACA1 | |
| Hydrochloric Acid SCHEMBL1846715 | 0.81 | MEN1 (0.36) | MEN1KMT2AGAACA1CA7 | |
| SCHEMBL8971824 | 0.81 | NAALAD2 (0.65) | NAALAD2MEN1KMT2AGAACA1 | |
| SCHEMBL3031112 | 0.81 | NAALAD2 (0.65) | NAALAD2MEN1KMT2AGAACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1918278-A1 | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases | Novartis AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| US-6410580-B1 | ANTIINFLAMMATORY AGENTS, RHEUMATIC DISEASES | NOVARTIS AG (CH) | 2002-06-25 | — | — | US | disclosed |
| US-6277987-B1 | FOR INHIBITING MATRIX-DEGRADING METALLOPROTEINASES IN MAMMALS | NOVARTIS AG (CH) | 2001-08-21 | — | — | US | disclosed |