Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 3/20 | 0.36 |
| ▸ | CA7 | P43166 | 2/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.36 |
| ▸ | CTSS | P25774 | 5/20 | 0.36 |
| ▸ | CTSK | P43235 | 5/20 | 0.36 |
| ▸ | HMGCR | P04035 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3785294 | 1.00 | MEN1 (0.40) | MEN1GAAKMT2ATDP1CYP2D6 | |
| SCHEMBL1486212 | 0.84 | NAALAD2 (0.44) | MEN1GAAKMT2ATDP1CA1 | |
| SCHEMBL5031613 | 0.84 | NAALAD2 (0.44) | MEN1GAAKMT2ATDP1CA1 | |
| SCHEMBL7414280 | 0.80 | TDP1 (0.36) | MEN1GAAKMT2ATDP1CA1 | |
| SCHEMBL16862490 | 0.79 | CTSK (0.36) | MEN1GAAKMT2ATDP1CA1 | |
| SCHEMBL11569761 | 0.79 | TDP1 (0.37) | MEN1GAAKMT2ATDP1TSHR | |
| SCHEMBL6793586 | 0.78 | TDP1 (0.50) | MEN1GAAKMT2ATDP1CA1 | |
| SCHEMBL16394247 | 0.78 | MEN1 (0.42) | MEN1GAAKMT2ATDP1CYP2D6 | |
| SCHEMBL16394248 | 0.78 | MEN1 (0.42) | MEN1GAAKMT2ATDP1CYP2D6 | |
| SCHEMBL15106687 | 0.78 | CYP17A1 (0.38) | HIF1ACA1CA12CA14CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5605904-A | ANTITUMOR AGENTS; ANTICARCINOGENIC AGENTS; FEWER SIDE EFFECTS | TANABE SEIYAKU CO., LTD. (JP) | 1997-02-25 | — | — | US | disclosed |
| US-5565569-A | ANTITUMOR AGENT | TANABE SEIYAKU CO., LTD. (JP) | 1996-10-15 | — | — | US | disclosed |
| EP-0608876-A1 | Ellipticine derivatives with antitumour activity | TANABE SEIYAKU CO., LTD. (JP) | 1994-08-03 | — | — | EP | disclosed |