Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 4/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15348810 | 0.82 | KDM4E (0.54) | KDM4EFFAR2RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL9413742 | 0.82 | ALDH1A1 (0.53) | ALDH1A1KDM4ERAB9ASMN1; SMN2NPC1 | |
| SCHEMBL14037407 | 0.82 | NR3C2 (0.55) | ALDH1A1MAPK1NR3C2KDM4ERAB9A | |
| SCHEMBL23565515 | 0.81 | RAB9A (0.53) | KDM4EFFAR2RAB9ASMN1; SMN2NPC1 | |
| Acetamide SCHEMBL28546989 | 0.81 | KDM4E (0.47) | KDM4EFFAR2RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL31741287 | 0.81 | PTK2 (0.62) | KDM4EFFAR2RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL1430301 | 0.81 | PTK2 (0.62) | KDM4EFFAR2RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL30804829 | 0.81 | KDM4E (0.41) | KDM4EFFAR2RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL29557328 | 0.81 | GRM5 (0.43) | KDM4EFFAR2RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL28550716 | 0.80 | TDP1 (0.47) | ALDH1A1KDM4EFFAR2RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957485-A2 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | Bayer Healthcare, LLC (US) | 2008-08-20 | — | — | EP | claimed |
| WO-2007064931-A2 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC (US) | 2007-06-07 | — | — | WO | claimed |
| EP-1373261-A2 | CYCLOPROPAHETEROCYCLES AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | MEDIVIR AB (SE) | 2004-01-02 | — | — | EP | claimed |
| WO-2002070516-A2 | CYCLOPROPAHETEROCYCLES AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | MEDIVIR AB (SE) | 2002-09-12 | — | — | WO | claimed |