Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4246422 | 0.88 | MAPT (0.50) | KDM4EMAPTAAK1KMT2AMAPK1 | |
| SCHEMBL7649879 | 0.80 | TDP1 (0.59) | KDM4EMAPTKMT2APOLBALDH1A1 | |
| SCHEMBL7656691 | 0.77 | KMT2A (0.47) | KDM4EMAPTKMT2APOLBALDH1A1 | |
| SCHEMBL4246459 | 0.77 | KDM4E (0.53) | KDM4EKMT2APOLBALDH1A1CYP1A2 | |
| SCHEMBL11910531 | 0.77 | KDM4E (0.66) | KDM4EMAPTKMT2AALDH1A1MAPK1 | |
| SCHEMBL12763768 | 0.77 | KDM4E (0.66) | KDM4EMAPTAAK1KMT2APOLB | |
| SCHEMBL13931447 | 0.75 | SMN1; SMN2 (0.42) | KDM4EKMT2APOLBALDH1A1KCNJ1 | |
| SCHEMBL5029790 | 0.75 | KDM4E (0.62) | KDM4EMAPTAAK1KMT2APOLB | |
| SCHEMBL4230805 | 0.74 | ALDH1A1 (0.56) | KDM4EMAPTKMT2APOLBALDH1A1 | |
| SCHEMBL7654762 | 0.73 | HTT (0.64) | KDM4EMAPTKMT2APOLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1993536-A2 | THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007103755-A2 | THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-09-13 | — | — | WO | disclosed |