Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 6/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4140425 | 0.91 | LMNA (0.42) | TNKSTNKS2HPGDLMNAMEN1 | |
| SCHEMBL4148644 | 0.79 | KDM4E (0.66) | TNKSTNKS2HPGDTSHRKDM4E | |
| SCHEMBL4142349 | 0.78 | TP53 (0.51) | TNKSTNKS2KMT2AALDH1A1HTT | |
| SCHEMBL4147903 | 0.78 | CASR (0.47) | HPGDLMNAMEN1KMT2ATSHR | |
| SCHEMBL10150419 | 0.77 | KDM4E (0.62) | TNKSTNKS2HPGDTSHRKDM4E | |
| SCHEMBL4144693 | 0.72 | TNKS (0.42) | TNKSTNKS2HPGDLMNATSHR | |
| SCHEMBL4143059 | 0.71 | TP53 (0.49) | KMT2AALDH1A1HSD17B10NPSR1 | |
| SCHEMBL13851592 | 0.69 | TP53 (0.50) | TSHRALDH1A1NPSR1 | |
| SCHEMBL4143019 | 0.69 | TP53 (0.49) | LMNAMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL4144206 | 0.68 | TP53 (0.51) | TNKSTNKS2KMT2AALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951244-A2 | CALCILYTIC COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007062370-A2 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-31 | — | — | WO | disclosed |