Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 5/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.42 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.40 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.40 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.40 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.40 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.40 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.40 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.40 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
| ▸ | CACNA1E | Q15878 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4150703 | 0.85 | HPGD (0.44) | HPGDSMN1; SMN2TSHRHTR2AKDM4E | |
| SCHEMBL4148575 | 0.85 | HPGD (0.44) | HPGDSMN1; SMN2TSHRHTR2AKDM4E | |
| SCHEMBL4142349 | 0.84 | TP53 (0.51) | TNKSTNKS2CACNB4CACNA1ACACNA1G | |
| SCHEMBL4148530 | 0.83 | HPGD (0.45) | HPGDTSHRHTR2AKDM4EALDH1A1 | |
| SCHEMBL13851604 | 0.82 | CNR1 (0.40) | HPGDLMNASMN1; SMN2HIF1AGAA | |
| SCHEMBL4140425 | 0.79 | LMNA (0.42) | TNKSTNKS2HPGDLMNAGAA | |
| SCHEMBL13851592 | 0.73 | TP53 (0.50) | SMN1; SMN2TSHRALDH1A1NPSR1 | |
| SCHEMBL3918061 | 0.73 | CNR1 (0.52) | HPGDLMNAGAAALDH1A1CNR1 | |
| SCHEMBL5031978 | 0.72 | TNKS (0.44) | TNKSTNKS2HPGDLMNAPARP10 | |
| SCHEMBL4143019 | 0.72 | TP53 (0.49) | LMNASMN1; SMN2HIF1ATSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137557-A1 | Calcilytic Compounds | SMITHKLINE BEECHAM CORPORATION | 2009-05-28 | — | — | US | disclosed |
| EP-1951244-A2 | CALCILYTIC COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007062370-A2 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137557-A1 | Calcilytic Compounds | CALCR, SOST, CALCB | TNKS 2115/4885TNKS2 1355/4885CACNB4 128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.