Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7017705 | 0.81 | KMT2A (0.46) | HTTTDP1KMT2AMEN1ATM | |
| SCHEMBL5908245 | 0.81 | KMT2A (0.39) | HTTTDP1KMT2AMEN1ATM | |
| SCHEMBL21383944 | 0.79 | KMT2A (0.38) | HTTTDP1KMT2AMEN1ATM | |
| SCHEMBL29947327 | 0.79 | KMT2A (0.38) | HTTTDP1KMT2AMEN1ATM | |
| SCHEMBL7018253 | 0.77 | ALDH1A1 (0.44) | HTTTDP1KMT2AMEN1ATM | |
| SCHEMBL7010124 | 0.77 | GAA (0.38) | HTTKMT2AMEN1ATMNPC1 | |
| SCHEMBL8385465 | 0.77 | CYP3A4 (0.40) | HTTTDP1KMT2AMEN1NOS3 | |
| SCHEMBL8141010 | 0.76 | HTT (0.37) | HTTTDP1KMT2AMEN1ALDH1A1 | |
| SCHEMBL29561608 | 0.76 | KMT2A (0.36) | HTTKMT2AMEN1ATMNPC1 | |
| SCHEMBL8561095 | 0.74 | MEN1 (0.42) | HTTTDP1KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954132-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | Renovis, Inc. (US) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007100758-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | RENOVIS, INC. (US) | 2007-09-07 | — | — | WO | disclosed |