Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 19/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5032123 | 0.81 | MAP2K1 (0.46) | MAP2K1 | |
| SCHEMBL5031197 | 0.79 | MAP2K1 (0.48) | MAP2K1 | |
| SCHEMBL5559975 | 0.76 | MAP2K1 (0.48) | MAP2K1EGFRKDR | |
| SCHEMBL5560203 | 0.76 | MAP2K1 (0.55) | MAP2K1EGFRKDR | |
| SCHEMBL391167 | 0.69 | MAP2K1 (0.66) | MAP2K1 | |
| SCHEMBL5031226 | 0.69 | MAP2K1 (0.48) | MAP2K1 | |
| SCHEMBL5032118 | 0.67 | MAP2K1 (0.36) | MAP2K1 | |
| SCHEMBL5032106 | 0.66 | MAP2K1 (0.37) | MAP2K1 | |
| SCHEMBL5031293 | 0.66 | MAP2K1 (0.44) | MAP2K1 | |
| SCHEMBL5031300 | 0.66 | MAP2K1 (0.35) | MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1922307-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2008-05-21 | — | — | EP | claimed |
| WO-2007044084-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2007-04-19 | — | — | WO | claimed |
| EP-1922307-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007044084-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2007-04-19 | — | — | WO | disclosed |