Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 18/20 | 0.48 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5560203 | 0.84 | MAP2K1 (0.55) | MAP2K1MAP2K2EGFRKDR | |
| SCHEMBL393658 | 0.82 | MAP2K1 (0.64) | MAP2K1MAP2K2 | |
| SCHEMBL5033731 | 0.78 | APLNR (0.36) | MAP2K1MAP2K2EGFRKDRNPC1 | |
| SCHEMBL5032058 | 0.76 | MAP2K1 (0.46) | MAP2K1EGFRKDR | |
| SCHEMBL392036 | 0.76 | MAP2K1 (0.45) | MAP2K1MAP2K2NPC1 | |
| SCHEMBL388633 | 0.74 | MAP2K1 (0.52) | MAP2K1MAP2K2NPC1 | |
| SCHEMBL27659435 | 0.74 | MAP2K1 (0.44) | MAP2K1MAP2K2 | |
| SCHEMBL5029045 | 0.72 | MAP2K1 (0.40) | MAP2K1MAP2K2NPC1 | |
| SCHEMBL5554883 | 0.72 | MAP2K1 (0.47) | MAP2K1MAP2K2 | |
| SCHEMBL5028995 | 0.71 | MAP2K2 (0.39) | MAP2K1MAP2K2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682138-A4 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-1682138-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005051301-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2005-06-09 | — | — | WO | disclosed |