Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | AGER | Q15109 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25779271 | 0.91 | KDM4E (0.43) | ALDH1A1SMN1; SMN2KMT2AMEN1KDM4E | |
| SCHEMBL30433281 | 0.84 | ALDH1A1 (0.34) | MAP4K1ALDH1A1SMN1; SMN2HPGDKMT2A | |
| SCHEMBL22684456 | 0.84 | ALDH1A1 (0.34) | MAP4K1ALDH1A1SMN1; SMN2HPGDKMT2A | |
| SCHEMBL3566913 | 0.84 | PIK3C3 (0.35) | MAP4K1ALDH1A1SMN1; SMN2HPGDKMT2A | |
| SCHEMBL12497167 | 0.81 | CYP1A2 (0.41) | MAP4K1ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL12411098 | 0.77 | CXCR2 (0.33) | MAP4K1ALDH1A1KDM4EMAPT | |
| SCHEMBL2140821 | 0.77 | EGLN2 (0.47) | ALDH1A1KDM4EMAPTALOX15CYP3A4 | |
| SCHEMBL2645441 | 0.77 | KDM4E (0.41) | ALDH1A1SMN1; SMN2HPGDKMT2AMEN1 | |
| SCHEMBL14818757 | 0.77 | NOS3 (0.45) | ALDH1A1SMN1; SMN2KMT2AKDM4EMAPT | |
| SCHEMBL4212744 | 0.75 | KDM4E (0.40) | ALDH1A1HPGDKMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8257686-B2 | Compositions and methods relating to prevention of chemotherapy-induced alopecia | HSF PHARMACEUTICALS S.A. (CH) | 2012-09-04 | — | — | US | disclosed |
| US-20080255643-A1 | COMPOSITIONS AND METHODS RELATING TO PREVENTION OF CHEMOTHERAPY-INDUCED ALOPECIA | HSF PHARMACEUTICALS S.A. (CH) | 2008-10-16 | — | — | US | disclosed |
| US-7405080-B2 | Compositions and methods relating to prevention of chemotherapy-induced alopecia | HSF PHARMACEUTICALS S.A. (CH) | 2008-07-29 | — | — | US | disclosed |
| EP-1427383-B1 | COMPOSITIONS AND METHODS RELATING TO PREVENTION OF CHEMOTHERAPY-INDUCED ALOPECIA | VOELLMY RICHARD (CH) | 2007-07-25 | — | — | EP | disclosed |
| EP-1427383-A1 | COMPOSITIONS AND METHODS RELATING TO PREVENTION OF CHEMOTHERAPY-INDUCED ALOPECIA | Voellmy, Richard (CH) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003020227-A1 | COMPOSITIONS AND METHODS RELATING TO PREVENTION OF CHEMOTHERAPY-INDUCED ALOPECIA | VOELLMY RICHARD (CH) | 2003-03-13 | — | — | WO | disclosed |
| US-20020001629-A1 | Pretreatment; inducing stress response | HSF PHARMACEUTICALS S.A. (CH) | 2002-01-03 | — | — | US | disclosed |