Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.36 |
| ▸ | ARG1 | P05089 | 1/20 | 0.32 |
| ▸ | ARG2 | P78540 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL5034081 | 0.94 | CYP1A2 (0.48) | CYP1A2CYP2C9HPGDMAPK1HIF1A | |
| Trolamine SCHEMBL220505 | 0.94 | CYP1A2 (0.52) | CYP1A2CYP2C9HPGDMAPK1HIF1A | |
| Trolamine SCHEMBL2160601 | 0.88 | CYP1A2 (0.48) | CYP1A2CYP2C9HPGDMAPK1HIF1A | |
| Trolamine SCHEMBL11520004 | 0.88 | CYP1A2 (0.58) | CYP1A2CYP2C9HPGDMAPK1HIF1A | |
| Trolamine SCHEMBL22749413 | 0.88 | CYP1A2 (0.52) | CYP1A2CYP2C9HPGDMAPK1HIF1A | |
| SCHEMBL21531945 | 0.85 | CYP1A2 (0.56) | CYP1A2CYP2C9HPGDMAPK1HIF1A | |
| SCHEMBL2845423 | 0.85 | CYP1A2 (0.50) | CYP1A2CYP2C9HPGDMAPK1HIF1A | |
| Diethylaminoethanol SCHEMBL3114 | 0.84 | — | — | |
| Diethylaminoethanol SCHEMBL10699915 | 0.84 | — | — | |
| SCHEMBL35602 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120309952-A1 | SMALL RNA PURIFICATION | PROMEGA CORPORATION (US) | 2012-12-06 | — | — | US | disclosed |
| EP-1996730-A2 | SMALL RNA PURIFICATION | PROMEGA CORPORATION (US) | 2008-12-03 | — | — | EP | disclosed |
| US-20070249821-A1 | Small RNA purification | PROMEGA CORPORATION (US) | 2007-10-25 | — | — | US | disclosed |
| WO-2007103485-A2 | SMALL RNA PURIFICATION | PROMEGA CORPORATION (US) | 2007-09-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249821-A1 | Small RNA purification | ZFR, EMG1, SNRPA1 | CYP1A2 4840/4885CYP2C9 4879/4885HPGD 4850/4885 |
| US-20120309952-A1 | SMALL RNA PURIFICATION | ZFR, EMG1, SNRPA1 | CYP1A2 4840/4885CYP2C9 4879/4885HPGD 4850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.