Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5516518 | 0.83 | TP53 (0.36) | ELANETLR7TLR8POLB | |
| SCHEMBL6221678 | 0.81 | DPP4 (0.40) | POLBDPP4 | |
| SCHEMBL18986860 | 0.79 | JAK2 (0.49) | TLR7TLR8JAK2ADORA2APDE4D | |
| SCHEMBL4756464 | 0.78 | JAK2 (0.54) | JAK2LMNAPOLBADORA2APDE4D | |
| SCHEMBL17670057 | 0.78 | JAK2 (0.40) | ELANETLR7TLR8JAK2POLB | |
| Isobutanol SCHEMBL9386343 | 0.77 | TLR7 (0.47) | TLR7TLR8JAK2LMNAPOLB | |
| SCHEMBL5528653 | 0.75 | GPR3 (0.48) | ELANEJAK2POLBNUDT1PDPK1 | |
| SCHEMBL6701755 | 0.75 | JAK2 (0.43) | JAK2POLBPDPK1CA12PARP1 | |
| SCHEMBL10743106 | 0.75 | JAK2 (0.46) | JAK2LMNAPOLBKMT2ASMN1; SMN2 | |
| Alcohol SCHEMBL5925469 | 0.75 | JAK2 (0.43) | ELANETLR7TLR8JAK2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937683-A1 | METHOD FOR 1H-IMIDAZOÝ4,5-c¨PYRIDINES AND ANALOGS THEREOF | Coley Pharmaceutical Group, Inc. (US) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007035935-A1 | METHOD FOR 1H-IMIDAZO[4,5-c]PYRIDINES AND ANALOGS THEREOF | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2007-03-29 | — | — | WO | disclosed |
| EP-1539752-B1 | PREPARATION OF 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINES VIA NOVEL IMIDAZO[4,5-C]QUINOLIN-4-CYANO AND 1H-IMIDAZO[4,5-C]QUINOLIN-4-CARBOXAMIDE INTERMEDIATES | TEVA GYOGYSZERGYAR ZARTKOERUEE (HU) | 2007-03-21 | — | — | EP | disclosed |
| EP-0575549-A1 | PROCESS FOR IMIDAZO 4,5-c]QUINOLIN-4-AMINES. | MINNESOTA MINING & MFG (US) | 1993-12-29 | — | — | EP | disclosed |
| EP-0145340-A2 | 1H-Imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amines | RIKER LABORATORIES, INC. (US) | 1985-06-19 | — | — | EP | disclosed |