Oxalic Acid

Oxalic Acid

SCHEMBL5033726

Cc1ccccc1OC(CCN(C)C)c1ccccc1.O=C(O)C(=O)O

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

OPRM1SLC6A4

The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A4 known ✓ P31645 3/20 0.57
OPRM1 known ✓ P35372 2/20 0.57
CYP1A2 P05177 3/20 0.57
CYP3A4 P08684 3/20 0.57
CYP2D6 P10635 3/20 0.57
SLC6A2 P23975 3/20 0.57
HRH3 Q9Y5N1 3/20 0.57
CHRM1 P11229 2/20 0.57
TSHR P16473 2/20 0.57
ADRA2B P18089 2/20 0.57
HTR2A P28223 2/20 0.57
HTR2C P28335 2/20 0.57
HRH1 P35367 2/20 0.57
DRD3 P35462 2/20 0.57
OPRK1 P41145 2/20 0.57
HTR2B P41595 2/20 0.57
SLC6A3 Q01959 2/20 0.57
KCNH2 Q12809 2/20 0.57
KLF10 Q13118 2/20 0.57
TP53 P04637 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3894545 0.93 CYP2D6 (0.64) CYP1A2CYP3A4CYP2D6SLC6A2SLC6A4
SCHEMBL8197707 0.93 CYP2D6 (0.64) CYP1A2CYP3A4CYP2D6SLC6A2SLC6A4
SCHEMBL5280197 0.89 CYP2D6 (0.57) CYP1A2CYP3A4CYP2D6SLC6A2SLC6A4
SCHEMBL7429997 0.89 CYP2D6 (0.57) CYP1A2CYP3A4CYP2D6SLC6A2SLC6A4
Oxalic Acid SCHEMBL7313636 0.88 SLC6A9 (0.47) CYP1A2CYP3A4CYP2D6SLC6A4HRH3
Oxalic Acid SCHEMBL7313643 0.88 SLC6A9 (0.47) CYP1A2CYP3A4CYP2D6SLC6A2SLC6A4
Oxalic Acid SCHEMBL7317340 0.86 KDM4E (0.69) SLC6A4HRH3HTR2AHRH1LMNA
Oxalic Acid SCHEMBL5287834 0.86 SLC6A9 (0.53) CYP1A2CYP3A4CYP2D6SLC6A2SLC6A4
Oxalic Acid SCHEMBL7314749 0.85 KDM4E (0.56) SLC6A2SLC6A4HRH3SLC6A9KDM4E
Oxalic Acid SCHEMBL7310142 0.85 SLC6A9 (0.51) SLC6A4HRH3HTR2AHRH1SLC6A9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008026227-A2 A PROCESS FOR THE PREPARATION OF ATOMOXETINE HYDROCHLORIDE MATRIX LABORATORIES LTD (IN) 2008-03-06 WO disclosed
US-4626549-A Treatment of obesity with aryloxyphenylpropylamines ELI LILLY AND COMPANY (US) 1986-12-02 US disclosed
US-4584404-A ANTIDEPRESSANT ELI LILLY AND COMPANY (US) 1986-04-22 US disclosed
US-4314081-A ANTIDEPRESSANTS ELI LILLY AND COMPANY (US) 1982-02-02 US disclosed
US-4194009-A ANTIDEPRESSANT ELI LILLY AND COMPANY (US) 1980-03-18 US disclosed
US-4018895-A Aryloxyphenylpropylamines in treating depression ELI LILLY AND COMPANY (US) 1977-04-19 US disclosed