Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 3/20 | 0.46 |
| ▸ | OPRM1 known ✓ | P35372 | 2/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 5/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | HRH1 | P35367 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7313636 | 0.91 | SLC6A9 (0.47) | SLC6A9SLC6A4HRH3ALDH1A1KDM4E | |
| Oxalic Acid SCHEMBL5033726 | 0.88 | CYP1A2 (0.57) | SLC6A9SLC6A4HRH3ALDH1A1KDM4E | |
| SCHEMBL8197707 | 0.81 | CYP2D6 (0.64) | SLC6A9SLC6A4HRH3CYP2D6CYP2C9 | |
| SCHEMBL3894545 | 0.81 | CYP2D6 (0.64) | SLC6A9SLC6A4HRH3CYP2D6CYP2C9 | |
| SCHEMBL6721958 | 0.80 | SLC6A4 (0.52) | SLC6A9SLC6A4HRH3SLC6A2HTR2A | |
| Oxalic Acid SCHEMBL7317340 | 0.80 | KDM4E (0.69) | SLC6A9SLC6A4HRH3ALDH1A1KDM4E | |
| Oxalic Acid SCHEMBL7310142 | 0.79 | SLC6A9 (0.51) | SLC6A9SLC6A4HRH3ALDH1A1KDM4E | |
| Oxalic Acid SCHEMBL7314749 | 0.79 | KDM4E (0.56) | SLC6A9SLC6A4HRH3ALDH1A1KDM4E | |
| Oxalic Acid SCHEMBL7316393 | 0.79 | SLC6A9 (0.51) | SLC6A9SLC6A4HRH3ALDH1A1KDM4E | |
| Oxalic Acid SCHEMBL1534190 | 0.78 | SLC6A9 (0.44) | SLC6A9SLC6A4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4626549-A | Treatment of obesity with aryloxyphenylpropylamines | ELI LILLY AND COMPANY (US) | 1986-12-02 | — | — | US | disclosed |
| US-4314081-A | ANTIDEPRESSANTS | ELI LILLY AND COMPANY (US) | 1982-02-02 | — | — | US | disclosed |
| US-4194009-A | ANTIDEPRESSANT | ELI LILLY AND COMPANY (US) | 1980-03-18 | — | — | US | disclosed |
| US-4018895-A | Aryloxyphenylpropylamines in treating depression | ELI LILLY AND COMPANY (US) | 1977-04-19 | — | — | US | disclosed |