Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRB1 | P17538 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | MMP7 | P09237 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | PAM | P19021 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | MME | P08473 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5043208 | 1.00 | CTRB1 (0.53) | CTRB1LMNAMMP2MMP3MMP7 | |
| SCHEMBL5033815 | 1.00 | CTRB1 (0.53) | CTRB1LMNAMMP2MMP3MMP7 | |
| SCHEMBL5036248 | 0.85 | ACACB (0.51) | MME | |
| SCHEMBL5036948 | 0.85 | ACACB (0.51) | MME | |
| SCHEMBL6319150 | 0.80 | MAPK1 (0.69) | CTRB1LMNACTSSCTSKPAM | |
| SCHEMBL6529461 | 0.80 | MAPK1 (0.69) | CTRB1LMNACTSSCTSKPAM | |
| SCHEMBL27904479 | 0.80 | HPGD (0.58) | CTRB1LMNACTSSCTSKPAM | |
| SCHEMBL17305286 | 0.80 | HPGD (0.58) | CTRB1LMNACTSSCTSKPAM | |
| SCHEMBL2089507 | 0.80 | MAPK1 (0.69) | CTRB1LMNACTSSCTSKPAM | |
| SCHEMBL14756047 | 0.80 | HPGD (0.58) | CTRB1LMNACTSSCTSKPAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1889903-A1 | Biocatalysts with amine acylase activity | Novartis AG (CH) | 2008-02-20 | — | — | EP | disclosed |
| EP-0954571-B1 | BIOCATALYSTS WITH AMINE ACYLASE ACTIVITY | NOVARTIS AG (CH) | 2007-08-29 | — | — | EP | disclosed |
| US-6235516-B1 | FROM RHODOCOCCUS GLOBERULUS, RHODOCOCCUS EQUI OR ARTHROBACTER AURESCENS | NOVARTIS AG (CH) | 2001-05-22 | — | — | US | disclosed |
| EP-0954571-A1 | BIOCATALYSTS WITH AMINE ACYLASE ACTIVITY | Novartis AG (CH) | 1999-11-10 | — | — | EP | disclosed |
| WO-1997041214-A1 | BIOCATALYSTS WITH AMINE ACYLASE ACTIVITY | NOVARTIS AG (CH) | 1997-11-06 | — | — | WO | disclosed |