Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 8/20 | 0.51 |
| ▸ | MME | P08473 | 2/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | PRKX | P51817 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.40 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.40 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CTSC | P53634 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5036248 | 1.00 | ACACB (0.51) | ACACBMMEPSMB5ACEROCK2 | |
| SCHEMBL7615213 | 0.87 | MME (0.46) | ACACBMMEPSMB5ACEROCK2 | |
| SCHEMBL8481611 | 0.86 | FPR2 (0.41) | ACACBMMEPSMB5ACEROCK2 | |
| SCHEMBL5033815 | 0.85 | CTRB1 (0.53) | MME | |
| SCHEMBL5043208 | 0.85 | CTRB1 (0.53) | MME | |
| SCHEMBL5033810 | 0.85 | CTRB1 (0.53) | MME | |
| SCHEMBL14195827 | 0.81 | ACACB (0.56) | ACACBMMEACEROCK2PRKACA | |
| SCHEMBL8926162 | 0.80 | HTT (0.45) | MMEROCK2PRKACARPS6KB1IRAK1 | |
| SCHEMBL10051044 | 0.80 | MME (0.50) | ACACBMME | |
| SCHEMBL10051046 | 0.80 | MME (0.50) | ACACBMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1889903-A1 | Biocatalysts with amine acylase activity | Novartis AG (CH) | 2008-02-20 | — | — | EP | disclosed |
| EP-0954571-B1 | BIOCATALYSTS WITH AMINE ACYLASE ACTIVITY | NOVARTIS AG (CH) | 2007-08-29 | — | — | EP | disclosed |
| US-6235516-B1 | FROM RHODOCOCCUS GLOBERULUS, RHODOCOCCUS EQUI OR ARTHROBACTER AURESCENS | NOVARTIS AG (CH) | 2001-05-22 | — | — | US | disclosed |
| EP-0954571-A1 | BIOCATALYSTS WITH AMINE ACYLASE ACTIVITY | Novartis AG (CH) | 1999-11-10 | — | — | EP | disclosed |
| WO-1997041214-A1 | BIOCATALYSTS WITH AMINE ACYLASE ACTIVITY | NOVARTIS AG (CH) | 1997-11-06 | — | — | WO | disclosed |