Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 6/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5028054 | 0.89 | CYP2A6 (0.46) | CYP2A6PGRHRH3MIFCA9 | |
| SCHEMBL5028042 | 0.86 | CYP2A6 (0.43) | CYP2A6PGRHRH3MIFCA9 | |
| SCHEMBL5034728 | 0.86 | HTR2B (0.44) | CYP2A6PGRHRH3MIFCA9 | |
| SCHEMBL7494225 | 0.86 | CYP2A6 (0.43) | CYP2A6PGRHRH3MIFCA9 | |
| SCHEMBL2096423 | 0.86 | CYP2A6 (0.43) | CYP2A6PGRHRH3MIFCA9 | |
| SCHEMBL5032875 | 0.85 | HRH3 (0.51) | CYP2A6PGRHRH3NOS3NOS1 | |
| SCHEMBL5033190 | 0.84 | HRH3 (0.42) | CYP2A6PGRHRH3MIFCA9 | |
| SCHEMBL11550694 | 0.77 | CYP2A6 (0.60) | CYP2A6PGRMIFCA9NOS3 | |
| SCHEMBL17401006 | 0.77 | CYP2A6 (0.48) | CYP2A6PGRMIFCA9NOS3 | |
| SCHEMBL7436627 | 0.76 | CYP2A6 (0.47) | CYP2A6PGRMIFCA9NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689732-A4 | CATIONIC SUBSTITUTED BENZOFURANS AS ANTIMICROBIAL AGENTS | UNIV NORTH CAROLINA (US) | 2008-10-22 | — | — | EP | disclosed |
| US-20080221191-A1 | Cationic substituted benzofurans as antimicrobial agents | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-09-11 | — | — | US | disclosed |
| US-7417158-B2 | Mycobacterium tuberculosis infection; protozoan pathogens; fungal pathogens | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2008-08-26 | — | — | US | disclosed |
| US-20080114047-A1 | Cationic substituted benzofurans as antimicrobial agents | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-05-15 | — | — | US | disclosed |
| EP-1689732-A2 | CATIONIC SUBSTITUTED BENZOFURANS AS ANTIMICROBIAL AGENTS | The University of North Carolina at Chapel Hill (US) | 2006-08-16 | — | — | EP | disclosed |
| US-20050197378-A1 | Cationic substituted benzofurans as antimicrobial agents | TIDWELL RICHARD R (US) | 2005-09-08 | — | — | US | disclosed |
| WO-2005055935-A2 | CATIONIC SUBSTITUTED BENZOFURANS AS ANTIMICROBIAL AGENTS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2005-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080114047-A1 | Cationic substituted benzofurans as antimicrobial agents | BET1, ARG2, BRDT | CYP2A6 4517/4885PGR 3549/4885HRH3 977/4885 |
| US-20050197378-A1 | Cationic substituted benzofurans as antimicrobial agents | BET1, ARG2, BRDT | CYP2A6 4517/4885PGR 3549/4885HRH3 977/4885 |
| US-20080221191-A1 | Cationic substituted benzofurans as antimicrobial agents | BET1, ARG2, BRDT | CYP2A6 4517/4885PGR 3549/4885HRH3 977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.