Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 8/20 | 0.60 |
| ▸ | MMP13 | P45452 | 1/20 | 0.58 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5032791 | 0.94 | ADAM17 (0.58) | ADAM17MMP13 | |
| SCHEMBL5032796 | 0.78 | ADAM17 (0.46) | ADAM17MMP13MMP2 | |
| SCHEMBL5032806 | 0.77 | MMP13 (0.51) | ADAM17MMP13MMP2 | |
| SCHEMBL4050333 | 0.77 | ADAM17 (0.76) | ADAM17MMP13MMP2 | |
| SCHEMBL6210129 | 0.76 | ADAM17 (0.64) | ADAM17MMP13MMP2 | |
| SCHEMBL6321457 | 0.76 | ADAM17 (0.74) | ADAM17MMP13MMP2 | |
| SCHEMBL6210103 | 0.76 | ADAM17 (0.73) | ADAM17MMP13MMP2 | |
| SCHEMBL4051714 | 0.76 | ADAM17 (0.71) | ADAM17MMP13MMP2 | |
| SCHEMBL4059418 | 0.75 | ADAM17 (1.00) | ADAM17MMP13MMP2 | |
| SCHEMBL6210085 | 0.75 | ADAM17 (0.70) | ADAM17MMP13MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628974-A4 | HYDANTOIN DERIVATIVES AS INHIBITORS OF TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME (TACE) | BRISTOL MYERS SQUIBB CO (US) | 2008-05-07 | — | — | EP | claimed |
| EP-1628974-A2 | HYDANTOIN DERIVATIVES AS INHIBITORS OF TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME (TACE) | Bristol-Myers Squibb Company (US) | 2006-03-01 | — | — | EP | claimed |
| WO-2004108086-A2 | HYDANTOIN DERIVATIVES AS INHIBITORS OF TUMOR NECROSIS FACTOR-α CONVERTING ENZYME (TACE) | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-12-16 | — | — | WO | claimed |