Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.44 |
| ▸ | CA9 | Q16790 | 4/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5032666 | 0.93 | NTRK1 (0.44) | KDM4EHTTKMT2A | |
| SCHEMBL5039162 | 0.91 | CA12 (0.47) | CA2CA9CA12CA1KDM4E | |
| SCHEMBL5041510 | 0.89 | CA2 (0.52) | CA2CA9CA12CA1CA4 | |
| SCHEMBL5034992 | 0.89 | MAPK1 (0.52) | CA2CA9CA12CA1KDM4E | |
| SCHEMBL5036088 | 0.88 | CA12 (0.42) | CA2CA9CA12CA1CA4 | |
| SCHEMBL5048263 | 0.86 | CA12 (0.53) | CA2CA9CA12CA1KDM4E | |
| SCHEMBL5035282 | 0.85 | CA2 (0.46) | CA2CA9CA12CA1 | |
| SCHEMBL5035013 | 0.85 | KDM4E (0.46) | KDM4EHTTKMT2A | |
| SCHEMBL5039198 | 0.84 | CA2 (0.48) | CA2CA9CA12CA1KDM4E | |
| SCHEMBL5034981 | 0.83 | KDM4E (0.45) | KDM4EHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761541-B1 | PYRRAZOLO-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | claimed |