Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 6/20 | 0.42 |
| ▸ | CA1 | P00915 | 6/20 | 0.42 |
| ▸ | CA2 | P00918 | 6/20 | 0.42 |
| ▸ | CA9 | Q16790 | 6/20 | 0.42 |
| ▸ | CA4 | P22748 | 4/20 | 0.42 |
| ▸ | CA7 | P43166 | 4/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5035007 | 0.92 | NTRK1 (0.41) | KDM4EHTTKMT2AMAPK1 | |
| SCHEMBL5039328 | 0.91 | CA2 (0.46) | CA12CA1CA2CA9CA4 | |
| SCHEMBL5032572 | 0.90 | KIF18A (0.45) | KDM4EHTTKMT2AMAPK1 | |
| SCHEMBL5039162 | 0.88 | CA12 (0.47) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL5035278 | 0.88 | CA2 (0.44) | CA12CA1CA2CA9CA4 | |
| SCHEMBL5032665 | 0.87 | KIF18A (0.46) | KDM4EHTTKMT2AMAPK1 | |
| SCHEMBL5049394 | 0.87 | CA12 (0.50) | CA12CA1CA2CA9SCN10A | |
| SCHEMBL5034992 | 0.86 | MAPK1 (0.52) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL5036557 | 0.83 | KMT2A (0.41) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL5039198 | 0.83 | CA2 (0.48) | CA12CA1CA2CA9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761541-B1 | PYRRAZOLO-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | claimed |