Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 15/20 | 0.45 |
| ▸ | PGR | P06401 | 11/20 | 0.45 |
| ▸ | AR | P10275 | 4/20 | 0.45 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 2/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12236933 | 1.00 | NR3C1 (0.45) | NR3C1PGRARNR3C2ESR1 | |
| SCHEMBL5035639 | 1.00 | NR3C1 (0.45) | NR3C1PGRARNR3C2ESR1 | |
| SCHEMBL5034784 | 0.88 | NR3C1 (0.49) | NR3C1PGRARNR3C2ESR1 | |
| SCHEMBL5034851 | 0.86 | NR3C1 (0.47) | NR3C1PGRARNR3C2ESR1 | |
| SCHEMBL2395432 | 0.86 | PGR (0.51) | NR3C1PGRARNR3C2ESR1 | |
| SCHEMBL2395438 | 0.86 | PGR (0.51) | NR3C1PGRARNR3C2ESR1 | |
| SCHEMBL12259431 | 0.86 | PGR (0.51) | NR3C1PGRARNR3C2ESR1 | |
| SCHEMBL5032361 | 0.85 | NR3C1 (0.46) | NR3C1PGRARNR3C2ESR1 | |
| SCHEMBL5132803 | 0.85 | PGR (0.47) | NR3C1PGRARNR3C2ESR1 | |
| SCHEMBL5035577 | 0.85 | NR3C1 (0.45) | NR3C1PGRARNR3C2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1944290-A1 | NOVEL 1-2-DIHYDROQUINOLINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2008-07-16 | — | — | EP | disclosed |