Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ketorolac. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 4/20 | 1.00 |
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 0.79 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | CDC42 | P60953 | 3/20 | 0.79 |
| ▸ | RAC1 | P63000 | 3/20 | 0.79 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.79 |
| ▸ | NPC1 | O15118 | 2/20 | 0.79 |
| ▸ | RAB9A | P51151 | 2/20 | 0.79 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.79 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.79 |
| ▸ | CA4 | P22748 | 5/20 | 0.53 |
| ▸ | CA9 | Q16790 | 4/20 | 0.53 |
| ▸ | CA12 | O43570 | 3/20 | 0.53 |
| ▸ | CA1 | P00915 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ketorolac SCHEMBL6378057 | 1.00 | PTGS2 (1.00) | PTGS2LMNAABCC4HTTBLM | |
| Ketorolac SCHEMBL977126 | 1.00 | PTGS2 (1.00) | PTGS2LMNAABCC4HTTBLM | |
| Ketorolac SCHEMBL7889476 | 0.99 | PTGS2 (0.98) | PTGS2LMNAABCC4HTTBLM | |
| Ketorolac SCHEMBL14892 | 0.89 | PTGS2 (1.00) | PTGS2LMNAABCC4HTTBLM | |
| Ketorolac SCHEMBL4103 | 0.89 | PTGS2 (1.00) | PTGS2LMNAABCC4HTTBLM | |
| Ketorolac SCHEMBL23466702 | 0.89 | PTGS2 (1.00) | PTGS2LMNAABCC4HTTBLM | |
| Ketorolac SCHEMBL14891 | 0.89 | PTGS2 (1.00) | PTGS2LMNAABCC4HTTBLM | |
| Ketorolac SCHEMBL6423894 | 0.87 | PTGS2 (0.76) | PTGS2LMNAABCC4HTTBLM | |
| Ketorolac SCHEMBL15661224 | 0.87 | PTGS2 (0.97) | PTGS2LMNAABCC4HTTBLM | |
| Ketorolac SCHEMBL20553125 | 0.87 | PTGS2 (0.97) | PTGS2LMNAABCC4HTTBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 20089 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122075220-A | Contact lens for treating xerophthalmia and preparation method thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122031499-A | Injectable hydrogel for promoting postoperative bone repair and preventing infection as well as preparation method and application thereof | 中国人民解放军海军军医大学 | 2026-05-15 | — | — | CN | claimed |
| EP-4740962-A1 | PHARMACEUTICAL COMPOSITION, FORMULATION CONTAINING PHARMACEUTICAL COMPOSITION, KIT CONTAINING PHARMACEUTICAL COMPOSITION, PREPARATION METHOD FOR PHARMACEUTICAL COMPOSITION, AND USE OF PHARMACEUTICAL COMPOSITION | Shanghai WD Pharmaceutical Co., Ltd (CN) | 2026-05-13 | — | — | EP | claimed |
| EP-4724839-A2 | CONTACT LENSES INCLUDING MEDICAMENTS AND METHODS OF MAKING AND USING SAME INCLUDING SLOW RELEASE OF GLAUCOMA TREATING DRUGS AND COMFORT ENHANCING DRUGS | Mediprint Ophthalmics Inc. (US) | 2026-04-15 | — | — | EP | claimed |
| US-12599556-B2 | Ophthalmic compositions | BIOTHERAVISION INC. (US) | 2026-04-14 | — | — | US | claimed |
| US-20260090984-A1 | CONTACT LENSES INCLUDING MEDICAMENTS AND METHODS OF MAKING AND USING SAME INCLUDING SLOW RELEASE OF GLAUCOMA TREATING DRUGS AND COMFORT ENHANCING DRUGS | MEDIPRINT OPHTHALMICS INC. (US) | 2026-04-02 | — | — | US | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| US-12569451-B2 | Bio-inspired tissue-adhesive hydrogel patch and uses thereof | Cellartgen Inc. (KR) | 2026-03-10 | — | — | US | claimed |
| CN-121573874-A | Advanced treatment process of sulfate pulping wastewater | 海南金海浆纸业有限公司 | 2026-02-27 | — | — | CN | claimed |
| EP-4695234-A1 | PYRIDO[3,4-D]PYRIMIDINONE AND PYRIMIDINE ARYL HYDROCARBON RECEPTOR ANTAGONISTS AND USES THEREOF | Allianthera (Suzhou) Biopharmaceutical Co., Ltd. (CN) | 2026-02-18 | — | — | EP | claimed |
| EP-0422681-A1 | Collagen containing ophthalmic formulation | SYNTEX (U.S.A.) INC. (US) | 1991-04-17 | — | — | EP | claimed |
| WO-1991004058-A2 | TREATMENT OF CONDITIONS AND DISEASE | NORPHARMCO INC. (CA) | 1991-04-04 | — | — | WO | claimed |
| EP-0380607-A4 | ANTI-IDIOTYPE ANTIBODIES TO ANTI-HUMAN HIGH MOLECULAR WEIGHT-MELANOMA ASSOCIATED ANTIGEN | — | 1990-12-12 | — | — | EP | claimed |
| EP-0390071-A1 | Preservative system for ophthalmic formulations | SYNTEX (U.S.A.) INC. (US) | 1990-10-03 | — | — | EP | claimed |
| EP-0380607-A1 | ANTI-IDIOTYPE ANTIBODIES TO ANTI-HUMAN HIGH MOLECULAR WEIGHT-MELANOMA ASSOCIATED ANTIGEN. | FERRONE SOLDANO (US) | 1990-08-08 | — | — | EP | claimed |
| WO-1989011296-A1 | ANTI-IDIOTYPE ANTIBODIES TO ANTI-HUMAN HIGH MOLECULAR WEIGHT-MELANOMA ASSOCIATED ANTIGEN | RAYCHAUDHURI, SYAMAL (US) | 1989-11-30 | — | — | WO | claimed |
| EP-0306984-A1 | Preservative system for ophtalmic formulations | SYNTEX (U.S.A.) INC. (US) | 1989-03-15 | — | — | EP | claimed |
| EP-0252130-A4 | SYSTEM AND METHOD OF DETECTING VISUAL FIELD DEFECTS. | UNIV SOUTHERN CALIFORNIA (US) | 1988-04-27 | — | — | EP | claimed |
| EP-0252130-A1 | SYSTEM AND METHOD OF DETECTING VISUAL FIELD DEFECTS. | UNIV SOUTHERN CALIFORNIA (US) | 1988-01-13 | — | — | EP | claimed |
| WO-1987004264-A1 | SYSTEM AND METHOD OF DETECTING VISUAL FIELD DEFECTS | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 1987-07-16 | — | — | WO | claimed |