Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ketorolac. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 4/20 | 1.00 |
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 0.79 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | CDC42 | P60953 | 3/20 | 0.79 |
| ▸ | RAC1 | P63000 | 3/20 | 0.79 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.79 |
| ▸ | NPC1 | O15118 | 2/20 | 0.79 |
| ▸ | RAB9A | P51151 | 2/20 | 0.79 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.79 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.79 |
| ▸ | CA4 | P22748 | 5/20 | 0.53 |
| ▸ | CA9 | Q16790 | 4/20 | 0.53 |
| ▸ | CA12 | O43570 | 3/20 | 0.53 |
| ▸ | CA1 | P00915 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ketorolac SCHEMBL5036 | 1.00 | PTGS2 (1.00) | PTGS2LMNAABCC4HTTBLM | |
| Ketorolac SCHEMBL6378057 | 1.00 | PTGS2 (1.00) | PTGS2LMNAABCC4HTTBLM | |
| Ketorolac SCHEMBL7889476 | 0.99 | PTGS2 (0.98) | PTGS2LMNAABCC4HTTBLM | |
| Ketorolac SCHEMBL14892 | 0.89 | PTGS2 (1.00) | PTGS2LMNAABCC4HTTBLM | |
| Ketorolac SCHEMBL4103 | 0.89 | PTGS2 (1.00) | PTGS2LMNAABCC4HTTBLM | |
| Ketorolac SCHEMBL23466702 | 0.89 | PTGS2 (1.00) | PTGS2LMNAABCC4HTTBLM | |
| Ketorolac SCHEMBL14891 | 0.89 | PTGS2 (1.00) | PTGS2LMNAABCC4HTTBLM | |
| Ketorolac SCHEMBL6423894 | 0.87 | PTGS2 (0.76) | PTGS2LMNAABCC4HTTBLM | |
| Ketorolac SCHEMBL15661224 | 0.87 | PTGS2 (0.97) | PTGS2LMNAABCC4HTTBLM | |
| Ketorolac SCHEMBL20553125 | 0.87 | PTGS2 (0.97) | PTGS2LMNAABCC4HTTBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200333637-A1 | SMART AUTOMATED CONTACT LENS CLEANSING DEVICE | GREESON AUSTIN (US) | 2020-10-22 | — | — | US | disclosed |
| US-20160206521-A1 | Gel-Based Compositions and Methods of Use | RODRIGUEZ ARCADIO MALDONADO (MX) | 2016-07-21 | — | — | US | disclosed |
| WO-2016100961-A1 | GEL-BASED COMPOSITIONS AND METHODS OF USE | RODRIGUEZ ARCADIO MALDONADO (US) | 2016-06-23 | — | — | WO | disclosed |
| US-9295692-B1 | Gel-based compositions and methods of use | RODRIGUEZ ARCADIO MALDONADO (MX) | 2016-03-29 | — | — | US | disclosed |
| EP-2844223-A1 | PHARMACEUTICAL NANOPARTICLES SHOWING IMPROVED MUCOSAL TRANSPORT | Kala Pharmaceuticals, Inc. (US) | 2015-03-11 | — | — | EP | disclosed |
| WO-2013166436-A1 | PHARMACEUTICAL NANOPARTICLES SHOWING IMPROVED MUCOSAL TRANSPORT | KALA PHARMACEUTICALS, INC. (US) | 2013-11-07 | — | — | WO | disclosed |
| US-20110021595-A1 | KETOROLAC TROMETHAMINE COMPOSITIONS FOR TREATING OR PREVENTING OCULAR PAIN | ALLERGAN, INC. (US) | 2011-01-27 | — | — | US | disclosed |
| EP-2054052-A1 | DRUG COMBINATION PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USING THEM | Vicus Therapeutics SPE 1, LLC (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008014471-A1 | DRUG COMBINATION PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USING THEM | VICUS THERAPEUTICS SPE 1, LLC (US) | 2008-01-31 | — | — | WO | disclosed |
| EP-1549742-A1 | METHOD FOR SELECTION OF COMPOUNDS WHICH INHIBIT CLONAL CELL GROWTH AND USE THEREOF | Tjötta, Enok (NO) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004055175-A1 | METHOD FOR SELECTION OF COMPOUNDS WHICH INHIBIT CLONAL CELL GROWTH AND USE THEREOF | TJOETTA ENOK (NO) | 2004-07-01 | — | — | WO | disclosed |
| EP-0799029-A1 | TRANSDERMAL DELIVERY SYSTEM WITH ADHESIVE OVERLAY AND PEEL SEAL DISC | THERATECH, INC. (US) | 1997-10-08 | — | — | EP | disclosed |
| US-5662925-A | FOR ADMINISTERING AN ACTIVE AGENT TO THE SKIN OR MUCOSA OF AN INDIVIDUAL | THERATECH, INC. (US) | 1997-09-02 | — | — | US | disclosed |
| EP-0707465-A4 | MONOLITHIC MATRIX TRANSDERMAL DELIVERY SYSTEM | CYGNUS THERAPEUTIC SYSTEMS (US) | 1997-04-16 | — | — | EP | disclosed |
| WO-1996019205-A1 | TRANSDERMAL DELIVERY SYSTEM WITH ADHESIVE OVERLAY AND PEEL SEAL DISC | THERATECH, INC. (US) | 1996-06-27 | — | — | WO | disclosed |
| EP-0707465-A1 | MONOLITHIC MATRIX TRANSDERMAL DELIVERY SYSTEM | CYGNUS, INC. (US) | 1996-04-24 | — | — | EP | disclosed |
| WO-1995033492-A9 | METHODS AND COMPOSITIONS FOR MODULATION OF WOUND HEALING | — | 1996-02-29 | — | — | WO | disclosed |
| WO-1995033492-A1 | METHODS AND COMPOSITIONS FOR MODULATION OF WOUND HEALING | HOUSTON BIOTECHNOLOGY INCORPORATED (US) | 1995-12-14 | — | — | WO | disclosed |