Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.41 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5037742 | 0.91 | MAPT (0.39) | SMN1; SMN2ALDH1A1KMT2ATNK2RAB9A | |
| SCHEMBL5036210 | 0.89 | MET (0.39) | ALDH1A1KMT2ACYP1A2METCDK9 | |
| SCHEMBL5042893 | 0.89 | MET (0.38) | SMN1; SMN2ALDH1A1KMT2ATNK2RAB9A | |
| SCHEMBL5037918 | 0.89 | MET (0.42) | SMN1; SMN2ALDH1A1KMT2ARAB9AMEN1 | |
| SCHEMBL5037838 | 0.88 | ALDH1A1 (0.39) | SMN1; SMN2ALDH1A1KMT2ATNK2RAB9A | |
| SCHEMBL5036471 | 0.88 | MET (0.40) | SMN1; SMN2ALDH1A1KMT2ARAB9AMEN1 | |
| SCHEMBL5033975 | 0.88 | MET (0.40) | SMN1; SMN2ALDH1A1KMT2ARAB9AMEN1 | |
| SCHEMBL5041033 | 0.87 | MET (0.40) | SMN1; SMN2ALDH1A1KMT2ARAB9AMEN1 | |
| SCHEMBL5042953 | 0.87 | ALDH1A1 (0.41) | SMN1; SMN2ALDH1A1KMT2ATNK2MET | |
| SCHEMBL5042946 | 0.86 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1KMT2ARAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432417-B1 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | AVENTIS PHARMA SA (FR) | 2008-02-20 | — | — | EP | disclosed |
| US-7041668-B2 | Substituted benzimidazole compounds and their use for the treatment of cancer | AVENTIS PHARMA S.A. (FR) | 2006-05-09 | — | — | US | disclosed |
| US-20050014811-A1 | Substituted benzimidazole compounds and their use for the treatment of cancer | AVENTIS PHARMA S.A. (FR) | 2005-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014811-A1 | Substituted benzimidazole compounds and their use for the treatment of cancer | CDKL3, CCNL2, CDKL1 | SMN1; SMN2 2426/4885ALDH1A1 1134/4885KMT2A 2114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.